Release-dependent variations in synaptic latency: a putative code for short- and long-term synaptic dynamics.

@article{citeulike:2202867, abstract = {In the cortex, synaptic latencies display small variations ( approximately 1-2 ms) that are generally considered to be negligible. We show here that the synaptic latency at monosynaptically connected pairs of L5 and CA3 pyramidal neurons is determined by the presynaptic release probability (Pr): synaptic latency being inversely correlated with the amplitude of the postsynaptic current and sensitive to manipulations of Pr. Changes in synaptic latency were also observed when Pr was physiologically regulated in short- and long-term synaptic plasticity. Paired-pulse depression and facilitation were respectively associated with increased and decreased synaptic latencies. Similarly, latencies were prolonged following induction of presynaptic LTD and reduced after LTP induction. We show using the dynamic-clamp technique that the observed covariation in latency and synaptic strength is a synergistic combination that significantly affects postsynaptic spiking. In conclusion, amplitude-related variation in latency represents a putative code for short- and long-term synaptic dynamics in cortical networks.}, address = {INSERM U641, Marseille, F-13916 France; Universit\'{e} de la M\'{e}diterran\'{e}e, Facult\'{e} de M\'{e}decine secteur nord, IFR 11, Marseille, F-13916 France.}, author = {Boudkkazi, S. and Carlier, E. and Ankri, N. and Caillard, O. and Giraud, P. and Fronzaroli-Molinieres, L. and Debanne, D. }, citeulike-article-id = {2202867}, doi = {10.1016/j.neuron.2007.10.037}, issn = {0896-6273}, journal = {Neuron}, keywords = {latency, stdp, synaptic\_dynamics}, month = {December}, number = {6}, pages = {1048--1060}, posted-at = {2008-05-13 16:24:45}, priority = {2}, title = {Release-dependent variations in synaptic latency: a putative code for short- and long-term synaptic dynamics.}, url = {http://dx.doi.org/10.1016/j.neuron.2007.10.037}, volume = {56}, year = {2007} }

TY - JOUR ID - citeulike:2202867 L3 - citeulike-article-id:2202867 TI - Release-dependent variations in synaptic latency: a putative code for short- and long-term synaptic dynamics. JF - Neuron VL - 56 IS - 6 SP - 1048 EP - 1060 AD - INSERM U641, Marseille, F-13916 France; Université de la Méditerranée, Faculté de Médecine secteur nord, IFR 11, Marseille, F-13916 France. SN - 0896-6273 N2 - In the cortex, synaptic latencies display small variations ( approximately 1-2 ms) that are generally considered to be negligible. We show here that the synaptic latency at monosynaptically connected pairs of L5 and CA3 pyramidal neurons is determined by the presynaptic release probability (Pr): synaptic latency being inversely correlated with the amplitude of the postsynaptic current and sensitive to manipulations of Pr. Changes in synaptic latency were also observed when Pr was physiologically regulated in short- and long-term synaptic plasticity. Paired-pulse depression and facilitation were respectively associated with increased and decreased synaptic latencies. Similarly, latencies were prolonged following induction of presynaptic LTD and reduced after LTP induction. We show using the dynamic-clamp technique that the observed covariation in latency and synaptic strength is a synergistic combination that significantly affects postsynaptic spiking. In conclusion, amplitude-related variation in latency represents a putative code for short- and long-term synaptic dynamics in cortical networks. KW - latency KW - stdp KW - synaptic_dynamics AU - Boudkkazi, S AU - Carlier, E AU - Ankri, N AU - Caillard, O AU - Giraud, P AU - Fronzaroli-Molinieres, L AU - Debanne, D PY - 2007/12/20/ UR - http://dx.doi.org/10.1016/j.neuron.2007.10.037 ER -