Beyond spike timing: the role of nonlinear plasticity and unreliable synapses.

@article{citeulike:2795503, abstract = {Spike-timing-dependent plasticity (STDP) strengthens synapses that are activated immediately before a postsynaptic spike, and weakens those that are activated after a spike. To prevent an uncontrolled growth of the synaptic strengths, weakening must dominate strengthening for uncorrelated spike times. However, this weight-normalization property would preclude Hebbian potentiation when the pre- and postsynaptic neurons are strongly active without specific spike-time correlations. We show that nonlinear STDP as inherent in the data of Markram et al. [(1997) Science 275:213-215] can preserve the benefits of both weight normalization and Hebbian plasticity, and hence can account for learning based on spike-time correlations and on mean firing rates. As examples we consider the moving-threshold property of the Bienenstock-Cooper-Munro rule, the development of direction-selective simple cells by changing short-term synaptic depression, and the joint adaptation of axonal and dendritic delays. Without threshold nonlinearity at low frequencies, the development of direction selectivity does not stabilize in a natural stimulation environment. Without synaptic unreliability there is no causal development of axonal and dendritic delays.}, address = {Physiological Institute, University of Bern, Buehleplatz 5, 3012 Bern, Switzerland. wsenn@cns.unibe.ch}, author = {Senn, W. }, citeulike-article-id = {2795503}, doi = {10.1007/s00422-002-0350-1}, issn = {0340-1200}, journal = {Biological cybernetics}, keywords = {reliability, stdp, synaptic\_plasticity, temporal\_coding}, month = {December}, number = {5-6}, pages = {344--355}, posted-at = {2008-05-13 16:45:37}, priority = {2}, title = {Beyond spike timing: the role of nonlinear plasticity and unreliable synapses.}, url = {http://dx.doi.org/10.1007/s00422-002-0350-1}, volume = {87}, year = {2002} }

TY - JOUR ID - citeulike:2795503 L3 - citeulike-article-id:2795503 TI - Beyond spike timing: the role of nonlinear plasticity and unreliable synapses. JF - Biological cybernetics VL - 87 IS - 5-6 SP - 344 EP - 355 AD - Physiological Institute, University of Bern, Buehleplatz 5, 3012 Bern, Switzerland. wsenn@cns.unibe.ch SN - 0340-1200 N2 - Spike-timing-dependent plasticity (STDP) strengthens synapses that are activated immediately before a postsynaptic spike, and weakens those that are activated after a spike. To prevent an uncontrolled growth of the synaptic strengths, weakening must dominate strengthening for uncorrelated spike times. However, this weight-normalization property would preclude Hebbian potentiation when the pre- and postsynaptic neurons are strongly active without specific spike-time correlations. We show that nonlinear STDP as inherent in the data of Markram et al. [(1997) Science 275:213-215] can preserve the benefits of both weight normalization and Hebbian plasticity, and hence can account for learning based on spike-time correlations and on mean firing rates. As examples we consider the moving-threshold property of the Bienenstock-Cooper-Munro rule, the development of direction-selective simple cells by changing short-term synaptic depression, and the joint adaptation of axonal and dendritic delays. Without threshold nonlinearity at low frequencies, the development of direction selectivity does not stabilize in a natural stimulation environment. Without synaptic unreliability there is no causal development of axonal and dendritic delays. KW - reliability KW - stdp KW - synaptic_plasticity KW - temporal_coding AU - Senn, W PY - 2002/12// UR - http://dx.doi.org/10.1007/s00422-002-0350-1 ER -