A biophysical model of synaptic plasticity and metaplasticity can account for the dynamics of the backward shift of hippocampal place fields.

@article{citeulike:2869541, abstract = {Hippocampal place cells in the rat undergo experience-dependent changes when the rat runs stereotyped routes. One such change, the backward shift of the place field center mass (COM), has been linked by previous modeling efforts to spike timing-dependent plasticity (STDP). However, these models did not account for the termination of the place field shift and they were based on an abstract implementation of STDP that ignores many of the features found in cortical plasticity. Here, instead of the abstract STDP model, we use a calcium-dependent plasticity (CaDP) learning rule that can account for many of the observed properties of cortical plasticity. We use the CaDP learning rule in combination with a model of metaplasticity to simulate place field dynamics. Without any major changes to the parameters of the original model, the present simulations account both for the initial rapid place field shift as well as for the subsequent slowing down of this shift. These results suggest that the CaDP model captures the essence of a general cortical mechanism of synaptic plasticity, which may underlie numerous forms of synaptic plasticity observed both in vivo and in vitro.}, address = {Neurobiology \& Anatomy, University of Texas Medical School at Houston, Houston, Texas, United States.}, author = {Yu, Xintian and Shouval, Harel Z Z. and Knierim, James J J. }, citeulike-article-id = {2869541}, doi = {10.1152/jn.01256.2007}, issn = {0022-3077}, journal = {Journal of neurophysiology}, keywords = {calcium, hippocampus, metaplasticity, stdp, synaptic\_plasticity, temporal\_coding}, month = {June}, posted-at = {2008-06-06 15:21:55}, priority = {2}, title = {A biophysical model of synaptic plasticity and metaplasticity can account for the dynamics of the backward shift of hippocampal place fields.}, url = {http://dx.doi.org/10.1152/jn.01256.2007}, year = {2008} }

TY - JOUR ID - citeulike:2869541 L3 - citeulike-article-id:2869541 TI - A biophysical model of synaptic plasticity and metaplasticity can account for the dynamics of the backward shift of hippocampal place fields. JF - Journal of neurophysiology AD - Neurobiology & Anatomy, University of Texas Medical School at Houston, Houston, Texas, United States. SN - 0022-3077 N2 - Hippocampal place cells in the rat undergo experience-dependent changes when the rat runs stereotyped routes. One such change, the backward shift of the place field center mass (COM), has been linked by previous modeling efforts to spike timing-dependent plasticity (STDP). However, these models did not account for the termination of the place field shift and they were based on an abstract implementation of STDP that ignores many of the features found in cortical plasticity. Here, instead of the abstract STDP model, we use a calcium-dependent plasticity (CaDP) learning rule that can account for many of the observed properties of cortical plasticity. We use the CaDP learning rule in combination with a model of metaplasticity to simulate place field dynamics. Without any major changes to the parameters of the original model, the present simulations account both for the initial rapid place field shift as well as for the subsequent slowing down of this shift. These results suggest that the CaDP model captures the essence of a general cortical mechanism of synaptic plasticity, which may underlie numerous forms of synaptic plasticity observed both in vivo and in vitro. KW - calcium KW - hippocampus KW - metaplasticity KW - stdp KW - synaptic_plasticity KW - temporal_coding AU - Yu, Xintian AU - Shouval, Harel Z AU - Knierim, James J PY - 2008/06/04/ UR - http://dx.doi.org/10.1152/jn.01256.2007 ER -