Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs

by: Ligang Wu, Joel G Belasco

Molecular Cell, Vol. 29, No. 1. (18 January 2008), pp. 1-7.

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Abstract

The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.

@article{wu08, abstract = {The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.}, author = {Wu, Ligang and Belasco, Joel G. }, citeulike-article-id = {2250332}, doi = {http://dx.doi.org/10.1016/j.molcel.2007.12.010}, journal = {Molecular Cell}, keywords = {microrna, microrna\_modes\_of\_action}, month = {January}, number = {1}, pages = {1--7}, posted-at = {2008-01-18 09:42:14}, priority = {3}, publisher = {Elsevier}, title = {Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs}, url = {http://dx.doi.org/10.1016/j.molcel.2007.12.010}, volume = {29}, year = {2008} }

RIS record

TY - JOUR ID - wu08 L3 - citeulike-article-id:2250332 TI - Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs JF - Molecular Cell VL - 29 IS - 1 SP - 1 EP - 7 PB - Elsevier N2 - The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved. KW - microrna KW - microrna_modes_of_action AU - Wu, Ligang AU - Belasco, Joel PY - 2008/01/18/ UR - http://dx.doi.org/10.1016/j.molcel.2007.12.010 ER -

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