Members of the miRNA-200 family regulate olfactory neurogenesis.

@article{citeulike:2478714, abstract = {MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.}, address = {Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.}, author = {Choi, P. S. and Zakhary, L. and Choi, W. Y. and Caron, S. and Alvarez-Saavedra, E. and Miska, E. A. and McManus, M. and Harfe, B. and Giraldez, A. J. and Horvitz, R. H. and Schier, A. F. and Dulac, C. }, citeulike-article-id = {2478714}, doi = {http://dx.doi.org/10.1016/j.neuron.2007.11.018}, issn = {0896-6273}, journal = {Neuron}, keywords = {microrna}, month = {January}, number = {1}, pages = {41--55}, posted-at = {2008-05-30 16:04:02}, priority = {2}, title = {Members of the miRNA-200 family regulate olfactory neurogenesis.}, url = {http://dx.doi.org/10.1016/j.neuron.2007.11.018}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:2478714 L3 - citeulike-article-id:2478714 TI - Members of the miRNA-200 family regulate olfactory neurogenesis. JF - Neuron VL - 57 IS - 1 SP - 41 EP - 55 AD - Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. SN - 0896-6273 N2 - MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates. KW - microrna AU - Choi, PS AU - Zakhary, L AU - Choi, WY AU - Caron, S AU - Alvarez-Saavedra, E AU - Miska, EA AU - McManus, M AU - Harfe, B AU - Giraldez, AJ AU - Horvitz, RH AU - Schier, AF AU - Dulac, C PY - 2008/01/10/ UR - http://dx.doi.org/10.1016/j.neuron.2007.11.018 ER -