Control of protein synthesis and mRNA degradation by microRNAs

@article{liu08, abstract = {MicroRNAs represent a large family of non-coding small RNAs that function as the major endogenous triggers for RNA interference. Hundreds of microRNAs have been identified through small RNA cloning, bioinformatic predictions, and high-throughput pyrosequencing. They are believed to suppress gene expression through post-transcriptional regulation via either translational repression or mRNA turnover. Over one third of human genes are predicted targets for microRNAs. However, even after extensive studies, the function of microRNAs and the precise mechanism by which they suppress gene expression remain elusive. Although controversy remains, recent advances have shined new light on how microRNAs regulate their targets. A better understanding of the mechanism should facilitate studies of their function.}, author = {Liu, Jidong }, booktitle = {Cell regulation}, citeulike-article-id = {2648960}, doi = {http://dx.doi.org/10.1016/j.ceb.2008.01.006}, journal = {Current Opinion in Cell Biology}, keywords = {microrna, microrna\_modes\_of\_action}, month = {April}, number = {2}, pages = {214--221}, posted-at = {2008-06-24 11:50:51}, priority = {0}, publisher = {Elsevier}, title = {Control of protein synthesis and mRNA degradation by microRNAs}, url = {http://dx.doi.org/10.1016/j.ceb.2008.01.006}, volume = {20}, year = {2008} }

TY - JOUR ID - liu08 L3 - citeulike-article-id:2648960 TI - Control of protein synthesis and mRNA degradation by microRNAs T2 - Cell regulation JF - Current Opinion in Cell Biology VL - 20 IS - 2 SP - 214 EP - 221 PB - Elsevier N2 - MicroRNAs represent a large family of non-coding small RNAs that function as the major endogenous triggers for RNA interference. Hundreds of microRNAs have been identified through small RNA cloning, bioinformatic predictions, and high-throughput pyrosequencing. They are believed to suppress gene expression through post-transcriptional regulation via either translational repression or mRNA turnover. Over one third of human genes are predicted targets for microRNAs. However, even after extensive studies, the function of microRNAs and the precise mechanism by which they suppress gene expression remain elusive. Although controversy remains, recent advances have shined new light on how microRNAs regulate their targets. A better understanding of the mechanism should facilitate studies of their function. KW - microrna KW - microrna_modes_of_action AU - Liu, Jidong PY - 2008/04// UR - http://dx.doi.org/10.1016/j.ceb.2008.01.006 ER -