Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs.

@article{citeulike:513370, abstract = {MicroRNAs comprise 1-3\% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target mRNAs. Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.}, address = {Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine New York, NY 10016. USA; Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138.USA.}, author = {Giraldez, Antonio J J. and Mishima, Yuichiro and Rihel, Jason and Grocock, Russell J J. and Van Dongen, Stijn and Inoue, Kunio and Enright, Anton J J. and Schier, Alexander F F. }, citeulike-article-id = {513370}, doi = {10.1126/science.1122689}, issn = {1095-9203}, journal = {Science}, keywords = {microrna, poster\_amigus}, month = {February}, posted-at = {2007-11-29 16:24:34}, priority = {3}, title = {Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs.}, url = {http://dx.doi.org/10.1126/science.1122689}, year = {2006} }

TY - JOUR ID - citeulike:513370 L3 - citeulike-article-id:513370 TI - Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs. JF - Science AD - Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine New York, NY 10016. USA; Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138.USA. SN - 1095-9203 N2 - MicroRNAs comprise 1-3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target mRNAs. Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis. KW - microrna KW - poster_amigus AU - Giraldez, Antonio J AU - Mishima, Yuichiro AU - Rihel, Jason AU - Grocock, Russell J AU - Van Dongen, Stijn AU - Inoue, Kunio AU - Enright, Anton J AU - Schier, Alexander F PY - 2006/02/16/ UR - http://dx.doi.org/10.1126/science.1122689 ER -