Genomic views of chromatin

by: Dana J Huebert, Bradley E Bernstein

Current Opinion in Genetics & Development, Vol. 15, No. 5. (October 2005), pp. 476-481.

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Abstract

With the availability of complete genome sequences for a number of organisms, a major challenge has become to understand how chromatin and its epigenetic modifications regulate genome function. High-throughput microarray and sequencing technologies are being combined with biochemical and immunological enrichment methods to obtain genome-scale views of chromatin in a variety of organisms. The data pinpoint novel, genomic elements and expansive chromatin domains, and offer insight into the functions of histone modifications. In parallel, state-of-the-art imaging techniques are being used to investigate higher-order chromatin organization, and are beginning to bridge our understanding of chromatin biology with that of chromosome structure.

@article{citeulike:340089, abstract = {With the availability of complete genome sequences for a number of organisms, a major challenge has become to understand how chromatin and its epigenetic modifications regulate genome function. High-throughput microarray and sequencing technologies are being combined with biochemical and immunological enrichment methods to obtain genome-scale views of chromatin in a variety of organisms. The data pinpoint novel, genomic elements and expansive chromatin domains, and offer insight into the functions of histone modifications. In parallel, state-of-the-art imaging techniques are being used to investigate higher-order chromatin organization, and are beginning to bridge our understanding of chromatin biology with that of chromosome structure.}, author = {Huebert, Dana J. and Bernstein, Bradley E. }, citeulike-article-id = {340089}, doi = {10.1016/j.gde.2005.08.001}, journal = {Current Opinion in Genetics \& Development}, keywords = {modifications, review, spatial-organization}, month = {October}, number = {5}, pages = {476--481}, posted-at = {2008-07-24 13:21:59}, priority = {4}, title = {Genomic views of chromatin}, url = {http://dx.doi.org/10.1016/j.gde.2005.08.001}, volume = {15}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:340089 L3 - citeulike-article-id:340089 TI - Genomic views of chromatin JF - Current Opinion in Genetics & Development VL - 15 IS - 5 SP - 476 EP - 481 N2 - With the availability of complete genome sequences for a number of organisms, a major challenge has become to understand how chromatin and its epigenetic modifications regulate genome function. High-throughput microarray and sequencing technologies are being combined with biochemical and immunological enrichment methods to obtain genome-scale views of chromatin in a variety of organisms. The data pinpoint novel, genomic elements and expansive chromatin domains, and offer insight into the functions of histone modifications. In parallel, state-of-the-art imaging techniques are being used to investigate higher-order chromatin organization, and are beginning to bridge our understanding of chromatin biology with that of chromosome structure. KW - modifications KW - review KW - spatial-organization AU - Huebert, Dana AU - Bernstein, Bradley PY - 2005/10// UR - http://dx.doi.org/10.1016/j.gde.2005.08.001 ER -

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