Intact mirror-tracing and impaired rotary-pursuit skill learning in patients with Huntington's disease: evidence for dissociable memory systems in skill learning.

@article{citeulike:2854032, abstract = {Skill learning in early-stage Huntington's disease (HD) patients was compared with that of normal controls on 2 perceptual-motor tasks, rotary pursuit and mirror tracing. HD patients demonstrated a dissociation between impaired rotary-pursuit and intact mirror-tracing skill learning. These results suggest that different forms of perceptual-motor skill learning are mediated by separable neural circuits. A striatal memory system may be essential for sequence or open-loop skill learning but not for skills that involve the closed-loop learning of novel visual-response mappings. It is hypothesized that working memory deficits in HD resulting from frontostriatal damage may account broadly for intact and impaired long-term learning and memory in HD patients.}, address = {Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA. gabrieli@psych.stanford.edu}, author = {Gabrieli, J. D. and Stebbins, G. T. and Singh, J. and Willingham, D. B. and Goetz, C. G. }, citeulike-article-id = {2854032}, issn = {0894-4105}, journal = {Neuropsychology}, month = {April}, number = {2}, pages = {272--281}, posted-at = {2008-06-01 08:57:26}, priority = {2}, title = {Intact mirror-tracing and impaired rotary-pursuit skill learning in patients with Huntington's disease: evidence for dissociable memory systems in skill learning.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9110333}, volume = {11}, year = {1997} }

TY - JOUR ID - citeulike:2854032 L3 - citeulike-article-id:2854032 TI - Intact mirror-tracing and impaired rotary-pursuit skill learning in patients with Huntington's disease: evidence for dissociable memory systems in skill learning. JF - Neuropsychology VL - 11 IS - 2 SP - 272 EP - 281 AD - Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA. gabrieli@psych.stanford.edu SN - 0894-4105 N2 - Skill learning in early-stage Huntington's disease (HD) patients was compared with that of normal controls on 2 perceptual-motor tasks, rotary pursuit and mirror tracing. HD patients demonstrated a dissociation between impaired rotary-pursuit and intact mirror-tracing skill learning. These results suggest that different forms of perceptual-motor skill learning are mediated by separable neural circuits. A striatal memory system may be essential for sequence or open-loop skill learning but not for skills that involve the closed-loop learning of novel visual-response mappings. It is hypothesized that working memory deficits in HD resulting from frontostriatal damage may account broadly for intact and impaired long-term learning and memory in HD patients. AU - Gabrieli, JD AU - Stebbins, GT AU - Singh, J AU - Willingham, DB AU - Goetz, CG PY - 1997/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/9110333 ER -