Correlation of corpus callosal morphometry with cognitive and motor function in periventricular leukomalacia.

@article{citeulike:598990, abstract = {PURPOSE: We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). METHODS: Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T (1)-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise T-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment. RESULTS: 29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment. CONCLUSION: Global and regional corpus callosal morphology can be quantified using deformation functions.}, address = {Department of Radiology and Radiological Sciences, The Johns Hopkins Medical Institutions, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.}, author = {Davatzikos, C. and Barzi, A. and Lawrie, T. and Hoon, A. H. and Melhem, E. R. }, citeulike-article-id = {598990}, doi = {http://dx.doi.org/10.1055/s-2003-43259}, issn = {0174-304X}, journal = {Neuropediatrics}, keywords = {brain, dbm, imaging, morphometry, mri, pediatric, shape, vbm}, month = {June}, number = {5}, pages = {247--252}, posted-at = {2006-04-24 23:54:29}, priority = {2}, title = {Correlation of corpus callosal morphometry with cognitive and motor function in periventricular leukomalacia.}, url = {http://dx.doi.org/10.1055/s-2003-43259}, volume = {34}, year = {2003} }

TY - JOUR ID - citeulike:598990 L3 - citeulike-article-id:598990 TI - Correlation of corpus callosal morphometry with cognitive and motor function in periventricular leukomalacia. JF - Neuropediatrics VL - 34 IS - 5 SP - 247 EP - 252 AD - Department of Radiology and Radiological Sciences, The Johns Hopkins Medical Institutions, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. SN - 0174-304X N2 - PURPOSE: We aim to correlate size and shape of corpus callosum with severity of motor and cognitive impairments in children with periventricular leukomalacia (PVL). METHODS: Children with PVL were stratified based on the severity of their motor and cognitive impairments. An age-matched control group was established. The corpus callosum was identified on mid-sagittal T (1)-weighted spin-echo (TR/TE: 550/15) MR images. The shape characteristics of the corpus callosum were measured with respect to a template via a shape transformation. The degree of callosal-shape transformation was quantified by a deformation function, which in turn was compared, using point-wise T-tests, for controls versus patients, diplegic versus quadriplegic patients, and patients with mild versus severe cognitive impairment. RESULTS: 29 children with spastic cerebral palsy and PVL and 32 age-matched controls were identified. In the PVL group, the entire corpus callosum was significantly smaller than in the control group (p value = 0.001). Significant differences existed in the shape of the corpus callosum between patients with diplegic versus quadriplegic and between patients with severe versus mild cognitive impairment. CONCLUSION: Global and regional corpus callosal morphology can be quantified using deformation functions. KW - brain KW - dbm KW - imaging KW - morphometry KW - mri KW - pediatric KW - shape KW - vbm AU - Davatzikos, C AU - Barzi, A AU - Lawrie, T AU - Hoon, AH AU - Melhem, ER PY - 2003/06// UR - http://dx.doi.org/10.1055/s-2003-43259 ER -