GeneRecon--a coalescent based tool for fine-scale association mapping.

by: T Mailund, MH Schierup, CN Pedersen, JN Madsen, J Hein, L Schauser

Bioinformatics, Vol. 22, No. 18. (15 September 2006), pp. 2317-2318.

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Abstract

SUMMARY: GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable. AVAILABILITY: The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/~mailund/GeneRecon CONTACT: mailund@birc.au.dk.

@article{citeulike:1931999, abstract = {SUMMARY: GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable. AVAILABILITY: The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/\~{}mailund/GeneRecon CONTACT: mailund@birc.au.dk.}, address = {Bioinformatics Research Center, University of Aarhus Høegh-Guldbergs Gade 10, DK-8000 Arhus C, Denmark. mailund@birc.au.dk}, author = {Mailund, T. and Schierup, M. H. and Pedersen, C. N. and Madsen, J. N. and Hein, J. and Schauser, L. }, citeulike-article-id = {1931999}, issn = {1460-2059}, journal = {Bioinformatics}, month = {September}, number = {18}, pages = {2317--2318}, posted-at = {2007-11-18 03:20:08}, priority = {2}, title = {GeneRecon--a coalescent based tool for fine-scale association mapping.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16632491}, volume = {22}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:1931999 L3 - citeulike-article-id:1931999 TI - GeneRecon--a coalescent based tool for fine-scale association mapping. JF - Bioinformatics VL - 22 IS - 18 SP - 2317 EP - 2318 AD - Bioinformatics Research Center, University of Aarhus Høegh-Guldbergs Gade 10, DK-8000 Arhus C, Denmark. mailund@birc.au.dk SN - 1460-2059 N2 - SUMMARY: GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and microsatellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis-Hastings sampling in the state space of genealogies. Input format, search strategy and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable. AVAILABILITY: The source code for GeneRecon, written in C++ and Scheme, is available under the GNU General Public License (GPL) at http://www.birc.au.dk/~mailund/GeneRecon CONTACT: mailund@birc.au.dk. AU - Mailund, T AU - Schierup, MH AU - Pedersen, CN AU - Madsen, JN AU - Hein, J AU - Schauser, L PY - 2006/09/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/16632491 ER -

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