Sepsis

by: O'Brien, Naeem A Ali, Scott K Aberegg, Edward Abraham

The American Journal of Medicine, Vol. 120, No. 12. (December 2007), pp. 1012-1022.

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Abstract

Sepsis is a clinical syndrome defined by a systemic response to infection. With progression to sepsis-associated organ failure (ie, severe sepsis) or hypotension (ie, septic shock) mortality increases. Sepsis is a cause of considerable mortality, morbidity, cost, and health care utilization. Abnormalities in the inflammation, immune, coagulation, oxygen delivery, and utilization pathways play a role in organ dysfunction and death. Early identification of septic patients allows for evidence-based interventions, such as prompt antibiotics, goal-directed resuscitation, and activated protein C. Appropriate care for sepsis may be more easily delivered by dividing this clinical entity into various stages and with changes in structures of delivery that extend across traditional boundaries. Better description of the molecular basis of the disease process also will allow for more targeted therapies.

@article{citeulike:2393104, abstract = {Sepsis is a clinical syndrome defined by a systemic response to infection. With progression to sepsis-associated organ failure (ie, severe sepsis) or hypotension (ie, septic shock) mortality increases. Sepsis is a cause of considerable mortality, morbidity, cost, and health care utilization. Abnormalities in the inflammation, immune, coagulation, oxygen delivery, and utilization pathways play a role in organ dysfunction and death. Early identification of septic patients allows for evidence-based interventions, such as prompt antibiotics, goal-directed resuscitation, and activated protein C. Appropriate care for sepsis may be more easily delivered by dividing this clinical entity into various stages and with changes in structures of delivery that extend across traditional boundaries. Better description of the molecular basis of the disease process also will allow for more targeted therapies.}, author = {O'Brien and Ali, Naeem A. and Aberegg, Scott K. and Abraham, Edward }, citeulike-article-id = {2393104}, doi = {10.1016/j.amjmed.2007.01.035}, journal = {The American Journal of Medicine}, month = {December}, number = {12}, pages = {1012--1022}, posted-at = {2008-02-18 09:27:54}, priority = {2}, title = {Sepsis}, url = {http://dx.doi.org/10.1016/j.amjmed.2007.01.035}, volume = {120}, year = {2007} }

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TY - JOUR ID - citeulike:2393104 L3 - citeulike-article-id:2393104 TI - Sepsis JF - The American Journal of Medicine VL - 120 IS - 12 SP - 1012 EP - 1022 N2 - Sepsis is a clinical syndrome defined by a systemic response to infection. With progression to sepsis-associated organ failure (ie, severe sepsis) or hypotension (ie, septic shock) mortality increases. Sepsis is a cause of considerable mortality, morbidity, cost, and health care utilization. Abnormalities in the inflammation, immune, coagulation, oxygen delivery, and utilization pathways play a role in organ dysfunction and death. Early identification of septic patients allows for evidence-based interventions, such as prompt antibiotics, goal-directed resuscitation, and activated protein C. Appropriate care for sepsis may be more easily delivered by dividing this clinical entity into various stages and with changes in structures of delivery that extend across traditional boundaries. Better description of the molecular basis of the disease process also will allow for more targeted therapies. AU - O'Brien AU - Ali, Naeem AU - Aberegg, Scott AU - Abraham, Edward PY - 2007/12// UR - http://dx.doi.org/10.1016/j.amjmed.2007.01.035 ER -

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