Empirical evaluation of complex epidemiologic study designs: workplace exposure and cancer.

@article{citeulike:2450458, abstract = {OBJECTIVE: To test whether a frequently used cohort-nested case-control study design exaggerated exposure-response relationships because of unrecognized study design bias. Our aim was to evaluate empirically the performance of this complex study design. METHODS: We applied the design from one such study to a closely related cohort using randomly selected probands as cases. Values for average exposures were assigned to probands equal to, greater than, and less than those assigned to controls (matches). RESULTS: Under certain lag scenarios, the nested study design produced higher average exposure in probands compared with their matches, even when this was clearly not the case. CONCLUSIONS: Empirical evaluation demonstrated that the study design produced a biased case-control lagged exposure difference under the null hypothesis and could not distinguish qualitatively between null and alternate hypotheses. Empirical evaluation provided a useful check on results generated from a complex study design. It gave useful insight into the behavior of the index study design that was not otherwise readily deducible.}, address = {Brush Wellman, Inc, 14710 West Portage River South Road, Elmore, OH 43416, USA. david\_deubner@brushwellman.com}, author = {Deubner, D. C. and Roth, H. D. and Levy, P. S. }, citeulike-article-id = {2450458}, doi = {10.1097/JOM.0b013e318145b28d}, issn = {1536-5948}, journal = {J Occup Environ Med}, month = {September}, number = {9}, pages = {953--959}, posted-at = {2008-03-01 09:41:26}, priority = {2}, title = {Empirical evaluation of complex epidemiologic study designs: workplace exposure and cancer.}, url = {http://dx.doi.org/10.1097/JOM.0b013e318145b28d}, volume = {49}, year = {2007} }

TY - JOUR ID - citeulike:2450458 L3 - citeulike-article-id:2450458 TI - Empirical evaluation of complex epidemiologic study designs: workplace exposure and cancer. JF - J Occup Environ Med VL - 49 IS - 9 SP - 953 EP - 959 AD - Brush Wellman, Inc, 14710 West Portage River South Road, Elmore, OH 43416, USA. david_deubner@brushwellman.com SN - 1536-5948 N2 - OBJECTIVE: To test whether a frequently used cohort-nested case-control study design exaggerated exposure-response relationships because of unrecognized study design bias. Our aim was to evaluate empirically the performance of this complex study design. METHODS: We applied the design from one such study to a closely related cohort using randomly selected probands as cases. Values for average exposures were assigned to probands equal to, greater than, and less than those assigned to controls (matches). RESULTS: Under certain lag scenarios, the nested study design produced higher average exposure in probands compared with their matches, even when this was clearly not the case. CONCLUSIONS: Empirical evaluation demonstrated that the study design produced a biased case-control lagged exposure difference under the null hypothesis and could not distinguish qualitatively between null and alternate hypotheses. Empirical evaluation provided a useful check on results generated from a complex study design. It gave useful insight into the behavior of the index study design that was not otherwise readily deducible. AU - Deubner, DC AU - Roth, HD AU - Levy, PS PY - 2007/09// UR - http://dx.doi.org/10.1097/JOM.0b013e318145b28d ER -