The pleiotropic functions of the Y-box-binding protein, YB-1.

@article{citeulike:2630862, abstract = {The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.}, address = {Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.}, author = {Kohno, K. and Izumi, H. and Uchiumi, T. and Ashizuka, M. and Kuwano, M. }, citeulike-article-id = {2630862}, doi = {http://dx.doi.org/10.1002/bies.10300}, issn = {0265-9247}, journal = {BioEssays : news and reviews in molecular, cellular and developmental biology}, month = {July}, number = {7}, pages = {691--698}, posted-at = {2008-04-05 01:47:05}, priority = {2}, title = {The pleiotropic functions of the Y-box-binding protein, YB-1.}, url = {http://dx.doi.org/10.1002/bies.10300}, volume = {25}, year = {2003} }

TY - JOUR ID - citeulike:2630862 L3 - citeulike-article-id:2630862 TI - The pleiotropic functions of the Y-box-binding protein, YB-1. JF - BioEssays : news and reviews in molecular, cellular and developmental biology VL - 25 IS - 7 SP - 691 EP - 698 AD - Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan. SN - 0265-9247 N2 - The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1. AU - Kohno, K AU - Izumi, H AU - Uchiumi, T AU - Ashizuka, M AU - Kuwano, M PY - 2003/07// UR - http://dx.doi.org/10.1002/bies.10300 ER -