Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity.

@article{citeulike:2690471, abstract = {Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-beta1 (TGF-beta)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-beta-directed microRNA:messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression.}, address = {Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. jiri.zavadil@med.nyu.edu}, author = {Zavadil, J. and Narasimhan, M. and Blumenberg, M. and Schneider, R. J. }, citeulike-article-id = {2690471}, doi = {10.1159/000101316}, issn = {1422-6421}, journal = {Cells, tissues, organs}, number = {1-3}, pages = {157--161}, posted-at = {2008-04-19 11:39:05}, priority = {2}, title = {Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity.}, url = {http://dx.doi.org/10.1159/000101316}, volume = {185}, year = {2007} }

TY - JOUR ID - citeulike:2690471 L3 - citeulike-article-id:2690471 TI - Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity. JF - Cells, tissues, organs VL - 185 IS - 1-3 SP - 157 EP - 161 AD - Department of Pathology and NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. jiri.zavadil@med.nyu.edu SN - 1422-6421 N2 - Noncoding microRNAs act as posttranscriptional repressors of gene function and are often deregulated in cancers and other diseases. Here we review recent findings on microRNA roles in tumorigenesis and report a microRNA profiling screen in transforming growth factor-beta1 (TGF-beta)-induced epithelial-mesenchymal transition (EMT) in human keratinocytes, a model of epithelial cell plasticity underlying epidermal injury and skin carcinogenesis. We describe a novel EMT-specific microRNA signature that includes induction of miR-21, a candidate oncogenic microRNA associated with carcinogenesis. By integrating the microRNA screen results with target prediction algorithms and gene expression profiling data, we outline a framework for TGF-beta-directed microRNA:messenger RNA (mRNA) regulatory circuitry and discuss its biological relevance for tumor progression. AU - Zavadil, J AU - Narasimhan, M AU - Blumenberg, M AU - Schneider, RJ PY - 2007/// UR - http://dx.doi.org/10.1159/000101316 ER -