S-adenosylmethionine and its products.

by: MA Grillo, S Colombatto

Amino acids, Vol. 34, No. 2. (February 2008), pp. 187-193.

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Abstract

S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.

@article{citeulike:2799374, abstract = {S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized.}, address = {Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universit\`{a} di Torino, Torino, Italy. Mariaangelica.grillo@unito.it}, author = {Grillo, M. A. and Colombatto, S. }, citeulike-article-id = {2799374}, doi = {10.1007/s00726-007-0500-9}, issn = {1438-2199}, journal = {Amino acids}, month = {February}, number = {2}, pages = {187--193}, posted-at = {2008-05-14 17:07:22}, priority = {2}, title = {S-adenosylmethionine and its products.}, url = {http://dx.doi.org/10.1007/s00726-007-0500-9}, volume = {34}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2799374 L3 - citeulike-article-id:2799374 TI - S-adenosylmethionine and its products. JF - Amino acids VL - 34 IS - 2 SP - 187 EP - 193 AD - Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Università di Torino, Torino, Italy. Mariaangelica.grillo@unito.it SN - 1438-2199 N2 - S-adenosylmethionine is involved in many processes, mainly methylation, polyamine synthesis and radical-based catalysis. It is synthesised through the catalysis of differently regulated enzyme forms. When it is used, the compounds formed are reutilized in different ways: in case of methylation, its end product is homocysteine, which can be remethylated to methionine, give rise to cysteine in the so-called transsulphuration pathway, or be released; in the case of polyamine synthesis, the methylthioadenosine formed is cleaved and gives rise to compounds which can be reutilized; during radical-based catalysis, 5-deoxyadenosine is formed and this, too, is cleaved and reutilized. AU - Grillo, MA AU - Colombatto, S PY - 2008/02// UR - http://dx.doi.org/10.1007/s00726-007-0500-9 ER -

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