CSCDB: The cAMP and cGMP signaling components database.

@article{citeulike:2803685, abstract = {Adenylate cyclases, guanylate cyclases, cyclic nucleotide phosphodiesterases, and cyclic nucleotide-binding proteins constitute the core of cAMP and cGMP signaling components. Using a combination of BLAST and profile search methods, we found that cyclic nucleotide-binding proteins exhibited diverse domain architectures. In addition to the domain architectures involved in the characterized functional groups, a cyclic nucleotide-binding domain was also fused to various domains involved in pyridine nucleotide-disulfide oxidoreductase, acetyltransferase, thioredoxin reductase, glutaminase, rhodanese, ferredoxin, and diguanylate cyclase, implying the versatile functions of cyclic nucleotide-binding proteins. We constructed the CSCDB database to accumulate the components of cAMP and cGMP signaling pathways in the complete genomes. User-friendly interfaces were created for easier browsing, searching, and downloading the data. Besides harboring the sequence itself, each entry provided detailed annotation information, such as sequence features, chromosomal localization, functional domains, transmembrane region, and sequence similarity against several major databases. Currently, CSCDB contains 4234 entries covering 466 organisms, including 35 eukaryotes, 382 bacteria, and 29 archaea. CSCDB can be freely accessible on the web at http://cscdb.com.cn.}, address = {Institute of Biomedical Informatics/Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325003, China.}, author = {Lu, Jianxin and Bao, Qiyu and Wu, Jinyu and Wang, Huan and Li, Dong and Xi, Yali and Wang, Shengqin and Yu, Shuaishuai and Qu, Jia }, citeulike-article-id = {2803685}, doi = {10.1016/j.ygeno.2008.03.012}, issn = {1089-8646}, journal = {Genomics}, keywords = {database, signaling}, month = {May}, posted-at = {2008-05-16 03:43:37}, priority = {2}, title = {CSCDB: The cAMP and cGMP signaling components database.}, url = {http://dx.doi.org/10.1016/j.ygeno.2008.03.012}, year = {2008} }

TY - JOUR ID - citeulike:2803685 L3 - citeulike-article-id:2803685 TI - CSCDB: The cAMP and cGMP signaling components database. JF - Genomics AD - Institute of Biomedical Informatics/Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou 325003, China. SN - 1089-8646 N2 - Adenylate cyclases, guanylate cyclases, cyclic nucleotide phosphodiesterases, and cyclic nucleotide-binding proteins constitute the core of cAMP and cGMP signaling components. Using a combination of BLAST and profile search methods, we found that cyclic nucleotide-binding proteins exhibited diverse domain architectures. In addition to the domain architectures involved in the characterized functional groups, a cyclic nucleotide-binding domain was also fused to various domains involved in pyridine nucleotide-disulfide oxidoreductase, acetyltransferase, thioredoxin reductase, glutaminase, rhodanese, ferredoxin, and diguanylate cyclase, implying the versatile functions of cyclic nucleotide-binding proteins. We constructed the CSCDB database to accumulate the components of cAMP and cGMP signaling pathways in the complete genomes. User-friendly interfaces were created for easier browsing, searching, and downloading the data. Besides harboring the sequence itself, each entry provided detailed annotation information, such as sequence features, chromosomal localization, functional domains, transmembrane region, and sequence similarity against several major databases. Currently, CSCDB contains 4234 entries covering 466 organisms, including 35 eukaryotes, 382 bacteria, and 29 archaea. CSCDB can be freely accessible on the web at http://cscdb.com.cn. KW - database KW - signaling AU - Lu, Jianxin AU - Bao, Qiyu AU - Wu, Jinyu AU - Wang, Huan AU - Li, Dong AU - Xi, Yali AU - Wang, Shengqin AU - Yu, Shuaishuai AU - Qu, Jia PY - 2008/05/07/ UR - http://dx.doi.org/10.1016/j.ygeno.2008.03.012 ER -