Diagnosis and Treatment of Hepatocellular Carcinoma

@article{citeulike:2806280, abstract = {The diagnosis and treatment of hepatocellular carcinoma (HCC) have witnessed major changes over the past decade. Until the early 1990s, HCC was a relatively rare malignancy, typically diagnosed at an advanced stage in a symptomatic patient, and there were no known effective palliative or therapeutic options. However, the rising incidence of HCC in several regions around the world coupled with emerging evidence for efficacy of screening in high-risk patients, liver transplantation as a curative option in select patients, ability to make definitive diagnosis using high-resolution imaging of the liver, less dependency on obtaining tissue diagnosis, and proven efficacy of transarterial chemoembolization and sorafenib as palliative therapy have improved the outlook for HCC patients. In this article, we present a summary of the most recent information on screening, diagnosis, staging, and different treatment modalities of HCC, as well as our recommended management approach.}, author = {El-Serag, Hashem B. and Marrero, Jorge A. and Rudolph, Lenhard and Reddy, Rajender K. }, citeulike-article-id = {2806280}, doi = {10.1053/j.gastro.2008.02.090}, journal = {Gastroenterology}, keywords = {hcc}, month = {May}, number = {6}, pages = {1752--1763}, posted-at = {2008-05-17 04:14:53}, priority = {2}, title = {Diagnosis and Treatment of Hepatocellular Carcinoma}, url = {http://dx.doi.org/10.1053/j.gastro.2008.02.090}, volume = {134}, year = {2008} }

TY - JOUR ID - citeulike:2806280 L3 - citeulike-article-id:2806280 TI - Diagnosis and Treatment of Hepatocellular Carcinoma JF - Gastroenterology VL - 134 IS - 6 SP - 1752 EP - 1763 N2 - The diagnosis and treatment of hepatocellular carcinoma (HCC) have witnessed major changes over the past decade. Until the early 1990s, HCC was a relatively rare malignancy, typically diagnosed at an advanced stage in a symptomatic patient, and there were no known effective palliative or therapeutic options. However, the rising incidence of HCC in several regions around the world coupled with emerging evidence for efficacy of screening in high-risk patients, liver transplantation as a curative option in select patients, ability to make definitive diagnosis using high-resolution imaging of the liver, less dependency on obtaining tissue diagnosis, and proven efficacy of transarterial chemoembolization and sorafenib as palliative therapy have improved the outlook for HCC patients. In this article, we present a summary of the most recent information on screening, diagnosis, staging, and different treatment modalities of HCC, as well as our recommended management approach. KW - hcc AU - El-Serag, Hashem AU - Marrero, Jorge AU - Rudolph, Lenhard AU - Reddy, Rajender PY - 2008/05// UR - http://dx.doi.org/10.1053/j.gastro.2008.02.090 ER -