Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors

@article{citeulike:2806284, abstract = {The hepatic complications of chronic hepatitis C (CHC) usually occur only after progression to cirrhosis has taken place. Progression to cirrhosis, however, is extremely variable and depends on a broad set of host and viral factors that modify the rate at which fibrosis develops in a given individual. Despite their inherent limitations, studies of the natural history of CHC have identified several nonmodifiable factors associated with disease progression. These include age at acquisition of infection, sex, and race. More recent reports suggest important roles for host genetic polymorphisms and viral factors. Of greater immediate relevance to patients and their clinicians are the potentially modifiable factors, which include excessive alcohol consumption; smoking (tobacco and marijuana); insulin resistance; and coinfection with hepatitis B virus, human immunodeficiency virus type 1, or schistosomiasis. Unfortunately, to date, there are no reliable predictive models that can accurately estimate the risk of CHC disease progression.}, author = {Missiha, Sharif B. and Ostrowski, Mario and Heathcote, Jenny E. }, citeulike-article-id = {2806284}, doi = {10.1053/j.gastro.2008.02.069}, journal = {Gastroenterology}, keywords = {hcv}, month = {May}, number = {6}, pages = {1699--1714}, posted-at = {2008-05-17 04:16:49}, priority = {2}, title = {Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors}, url = {http://dx.doi.org/10.1053/j.gastro.2008.02.069}, volume = {134}, year = {2008} }

TY - JOUR ID - citeulike:2806284 L3 - citeulike-article-id:2806284 TI - Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors JF - Gastroenterology VL - 134 IS - 6 SP - 1699 EP - 1714 N2 - The hepatic complications of chronic hepatitis C (CHC) usually occur only after progression to cirrhosis has taken place. Progression to cirrhosis, however, is extremely variable and depends on a broad set of host and viral factors that modify the rate at which fibrosis develops in a given individual. Despite their inherent limitations, studies of the natural history of CHC have identified several nonmodifiable factors associated with disease progression. These include age at acquisition of infection, sex, and race. More recent reports suggest important roles for host genetic polymorphisms and viral factors. Of greater immediate relevance to patients and their clinicians are the potentially modifiable factors, which include excessive alcohol consumption; smoking (tobacco and marijuana); insulin resistance; and coinfection with hepatitis B virus, human immunodeficiency virus type 1, or schistosomiasis. Unfortunately, to date, there are no reliable predictive models that can accurately estimate the risk of CHC disease progression. KW - hcv AU - Missiha, Sharif AU - Ostrowski, Mario AU - Heathcote, Jenny PY - 2008/05// UR - http://dx.doi.org/10.1053/j.gastro.2008.02.069 ER -