Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study

@article{citeulike:2943713, abstract = {Abstract Aims/hypothesis\ \ The aim of this study was to examine the association between baseline body iron stores and new-onset diabetes. Subjects and methods\ \ We studied the association between baseline serum ferritin concentration and type 2 diabetes in 360 clinically incident diabetes cases and 758 controls nested within the EPIC (European Prospective Investigation of Cancer)-Norfolk Cohort Study. Serum ferritin levels were categorised into five groups: sex-specific quartiles of the normal range of ferritin and a group with clinically raised ferritin below levels indicative of haemochromatosis. Results\ \ Baseline serum ferritin was higher among cases than control participants (geometric mean: men 96.6 vs 67.8\ ng/ml, respectively, p \< 0.001; women 45.9 vs 34.8\ ng/ml, respectively, p = 0.005). In analyses adjusted for known risk factors (age, BMI, sex, family history, physical activity, smoking habit) and dietary factors measured by 7-day food diary, the risk of diabetes was markedly elevated in participants with clinically raised ferritin compared with the lowest quartile (odds ratio [OR] 7.4, 95\% CI 3.5–15.4). Further adjustment for potential confounding by inflammation (C-reactive protein, IL-6 and fibrinogen) had no material impact on the observed association, while adjustment for hepatic enzymes (alanine aminotransferase and γ glutamyl transferase) and adiponectin attenuated the magnitude of association, but it remained statistically significant (OR 3.2 [1.3–7.6]). Conclusions/interpretation\ \ Serum ferritin is an important and independent predictor of the development of diabetes. This finding may have important implications for understanding the aetiology of diabetes.}, author = {Forouhi, N. and Harding, A. and Allison, M. and Sandhu, M. and Welch, A. and Luben, R. and Bingham, S. and Khaw, K. and Wareham, N. }, citeulike-article-id = {2943713}, doi = {http://dx.doi.org/10.1007/s00125-007-0604-5}, journal = {Diabetologia}, keywords = {dm, iron}, month = {May}, number = {5}, pages = {949--956}, posted-at = {2008-06-30 12:25:14}, priority = {2}, title = {Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study}, url = {http://dx.doi.org/10.1007/s00125-007-0604-5}, volume = {50}, year = {2007} }

TY - JOUR ID - citeulike:2943713 L3 - citeulike-article-id:2943713 TI - Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study JF - Diabetologia VL - 50 IS - 5 SP - 949 EP - 956 N2 - Abstract Aims/hypothesis  The aim of this study was to examine the association between baseline body iron stores and new-onset diabetes. Subjects and methods  We studied the association between baseline serum ferritin concentration and type 2 diabetes in 360 clinically incident diabetes cases and 758 controls nested within the EPIC (European Prospective Investigation of Cancer)-Norfolk Cohort Study. Serum ferritin levels were categorised into five groups: sex-specific quartiles of the normal range of ferritin and a group with clinically raised ferritin below levels indicative of haemochromatosis. Results  Baseline serum ferritin was higher among cases than control participants (geometric mean: men 96.6 vs 67.8 ng/ml, respectively, p < 0.001; women 45.9 vs 34.8 ng/ml, respectively, p = 0.005). In analyses adjusted for known risk factors (age, BMI, sex, family history, physical activity, smoking habit) and dietary factors measured by 7-day food diary, the risk of diabetes was markedly elevated in participants with clinically raised ferritin compared with the lowest quartile (odds ratio [OR] 7.4, 95% CI 3.5–15.4). Further adjustment for potential confounding by inflammation (C-reactive protein, IL-6 and fibrinogen) had no material impact on the observed association, while adjustment for hepatic enzymes (alanine aminotransferase and γ glutamyl transferase) and adiponectin attenuated the magnitude of association, but it remained statistically significant (OR 3.2 [1.3–7.6]). Conclusions/interpretation  Serum ferritin is an important and independent predictor of the development of diabetes. This finding may have important implications for understanding the aetiology of diabetes. KW - dm KW - iron AU - Forouhi, N AU - Harding, A AU - Allison, M AU - Sandhu, M AU - Welch, A AU - Luben, R AU - Bingham, S AU - Khaw, K AU - Wareham, N PY - 2007/05/04/ UR - http://dx.doi.org/10.1007/s00125-007-0604-5 ER -