Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality.

@article{citeulike:2971367, abstract = {BACKGROUND: Histidine is considered as an antiinflammatory and antioxidant factor. Histidine deficiency may contribute to an impaired nutritional state in patients with chronic kidney disease (CKD). OBJECTIVE: We aimed to investigate the consequences of plasma histidine deficiency in CKD patients. DESIGN: CKD patients (n = 325; 203 M) with a median age of 54 y (range: 19-70 y) were evaluated shortly before the beginning of renal replacement therapy. The median glomerular filtration rate was 6.4 mL/min (range: 0.8-14.5 mL/min). Nutritional status was assessed by subjective global assessment. Survival was followed for up to 60 mo; 101 patients died. RESULTS: Plasma histidine concentrations were significantly lower in CKD patients with history of cardiovascular disease, presence of plaques, protein-energy wasting, and inflammation. Plasma histidine was negatively associated with age, C-reactive protein, interleukin-6, leukocytes, thrombocytes, fibrinogen, hepatocyte growth factor, adhesion molecules, insulin-like growth factor-1, and 8-hydroxy-2'-deoxyguanosine and was positively associated with handgrip strength, hemoglobin, S-albumin and fetuin-A. A multivariate regression analysis showed that histidine concentrations were independently associated with hepatocyte growth factor, hemoglobin, and fetuin-A. In unadjusted analysis, a low histidine concentration was associated with all-cause mortality (log rank chi-square test = 8.9; P = 0.002). After adjustment for age, sex, cardiovascular disease, inflammation, diabetes mellitus, serum S-albumin, and amino acid supplementation, the association between low histidine and mortality remained significant (hazard ratio: 1.55; 95\% CI: 1.02, 2.40; P < 0.05). CONCLUSION: Low plasma concentrations of histidine are associated with protein-energy wasting, inflammation, oxidative stress, and greater mortality in CKD patients.}, address = {Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.}, author = {Watanabe, M. and Suliman, M. E. and Qureshi, A. R. and Garcia-Lopez, E. and B\'{a}r\'{a}ny, P. and Heimb\"{u}rger, O. and Stenvinkel, P. and Lindholm, B. }, citeulike-article-id = {2971367}, issn = {0002-9165}, journal = {The American journal of clinical nutrition}, keywords = {hd, inflammation, mortality, ros}, month = {June}, number = {6}, pages = {1860--1866}, posted-at = {2008-07-08 04:51:50}, priority = {2}, title = {Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18541578}, volume = {87}, year = {2008} }

TY - JOUR ID - citeulike:2971367 L3 - citeulike-article-id:2971367 TI - Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality. JF - The American journal of clinical nutrition VL - 87 IS - 6 SP - 1860 EP - 1866 AD - Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. SN - 0002-9165 N2 - BACKGROUND: Histidine is considered as an antiinflammatory and antioxidant factor. Histidine deficiency may contribute to an impaired nutritional state in patients with chronic kidney disease (CKD). OBJECTIVE: We aimed to investigate the consequences of plasma histidine deficiency in CKD patients. DESIGN: CKD patients (n = 325; 203 M) with a median age of 54 y (range: 19-70 y) were evaluated shortly before the beginning of renal replacement therapy. The median glomerular filtration rate was 6.4 mL/min (range: 0.8-14.5 mL/min). Nutritional status was assessed by subjective global assessment. Survival was followed for up to 60 mo; 101 patients died. RESULTS: Plasma histidine concentrations were significantly lower in CKD patients with history of cardiovascular disease, presence of plaques, protein-energy wasting, and inflammation. Plasma histidine was negatively associated with age, C-reactive protein, interleukin-6, leukocytes, thrombocytes, fibrinogen, hepatocyte growth factor, adhesion molecules, insulin-like growth factor-1, and 8-hydroxy-2'-deoxyguanosine and was positively associated with handgrip strength, hemoglobin, S-albumin and fetuin-A. A multivariate regression analysis showed that histidine concentrations were independently associated with hepatocyte growth factor, hemoglobin, and fetuin-A. In unadjusted analysis, a low histidine concentration was associated with all-cause mortality (log rank chi-square test = 8.9; P = 0.002). After adjustment for age, sex, cardiovascular disease, inflammation, diabetes mellitus, serum S-albumin, and amino acid supplementation, the association between low histidine and mortality remained significant (hazard ratio: 1.55; 95% CI: 1.02, 2.40; P < 0.05). CONCLUSION: Low plasma concentrations of histidine are associated with protein-energy wasting, inflammation, oxidative stress, and greater mortality in CKD patients. KW - hd KW - inflammation KW - mortality KW - ros AU - Watanabe, M AU - Suliman, ME AU - Qureshi, AR AU - Garcia-Lopez, E AU - Bárány, P AU - Heimbürger, O AU - Stenvinkel, P AU - Lindholm, B PY - 2008/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/18541578 ER -