Association of serum fetuin-A levels with mortality in dialysis patients.

@article{citeulike:2997767, abstract = {Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13\%. There was a significant 17\% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients.}, address = {Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands. mherm@sint.azm.nl}, author = {Hermans, M. M. and Brandenburg, V. and Ketteler, M. and Kooman, J. P. and van der Sande, F. M. and Boeschoten, E. W. and Leunissen, K. M. and Krediet, R. T. and Dekker, F. W. and }, citeulike-article-id = {2997767}, doi = {http://dx.doi.org/10.1038/sj.ki.5002178}, issn = {0085-2538}, journal = {Kidney international}, keywords = {calcification, cv, fetuin, hd, mortality}, month = {July}, number = {2}, pages = {202--207}, posted-at = {2008-07-14 03:04:00}, priority = {2}, title = {Association of serum fetuin-A levels with mortality in dialysis patients.}, url = {http://dx.doi.org/10.1038/sj.ki.5002178}, volume = {72}, year = {2007} }

TY - JOUR ID - citeulike:2997767 L3 - citeulike-article-id:2997767 TI - Association of serum fetuin-A levels with mortality in dialysis patients. JF - Kidney international VL - 72 IS - 2 SP - 202 EP - 207 AD - Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands. mherm@sint.azm.nl SN - 0085-2538 N2 - Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13%. There was a significant 17% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients. KW - calcification KW - cv KW - fetuin KW - hd KW - mortality AU - Hermans, MM AU - Brandenburg, V AU - Ketteler, M AU - Kooman, JP AU - van der Sande, FM AU - Boeschoten, EW AU - Leunissen, KM AU - Krediet, RT AU - Dekker, FW PY - 2007/07// UR - http://dx.doi.org/10.1038/sj.ki.5002178 ER -