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Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type.

by: R Grantham, C Gautier, M Gouy
Nucleic acids research, Vol. 8, No. 9. (10 May 1980), pp. 1893-1912.


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The poor printing of our previous Figure 2 (1) is corrected. Codon usage in mRNA sequences just published is also given. A new correspondence analysis is done, based on simultaneous comparison in all mRNA of use of the 61 codons. This analysis reinforces our claim that most genes in a genome, or genome type, have the same coding strategy; that is, they show similar choices among synonymous codons, or among degenerate bases (2). Like analysis on frequency variation in the amino acids coded reveals an entirely different pattern.


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