Compositional constraints and genome evolution.

by: G Bernardi, G Bernardi

Journal of molecular evolution, Vol. 24, No. 1-2. (1986), pp. 1-11.

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Abstract

Nucleotide sequences of all genomes are subject to compositional constraints that affect, to about the same extent, both coding and noncoding sequences; influence not only the structure and function of the genome, but also those of transcripts and proteins; are the result of environmental pressures; and largely control the fixation of mutations. These findings indicate that noncoding sequences are associated with biological functions; that the organismal phenotype comprises two components, the classical phenotype, corresponding to the "gene products," and a "genome phenotype," which is defined by the compositional constraints; and that natural selection plays a more important role in genome evolution than do random events.

@article{BB86, abstract = {Nucleotide sequences of all genomes are subject to compositional constraints that affect, to about the same extent, both coding and noncoding sequences; influence not only the structure and function of the genome, but also those of transcripts and proteins; are the result of environmental pressures; and largely control the fixation of mutations. These findings indicate that noncoding sequences are associated with biological functions; that the organismal phenotype comprises two components, the classical phenotype, corresponding to the "gene products," and a "genome phenotype," which is defined by the compositional constraints; and that natural selection plays a more important role in genome evolution than do random events.}, author = {Bernardi, G. and Bernardi, G. }, citeulike-article-id = {2941799}, issn = {0022-2844}, journal = {Journal of molecular evolution}, keywords = {hgt}, number = {1-2}, pages = {1--11}, posted-at = {2008-06-29 16:40:40}, priority = {2}, title = {Compositional constraints and genome evolution.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/3104608}, volume = {24}, year = {1986} }

RIS record

TY - JOUR ID - BB86 L3 - citeulike-article-id:2941799 TI - Compositional constraints and genome evolution. JF - Journal of molecular evolution VL - 24 IS - 1-2 SP - 1 EP - 11 SN - 0022-2844 N2 - Nucleotide sequences of all genomes are subject to compositional constraints that affect, to about the same extent, both coding and noncoding sequences; influence not only the structure and function of the genome, but also those of transcripts and proteins; are the result of environmental pressures; and largely control the fixation of mutations. These findings indicate that noncoding sequences are associated with biological functions; that the organismal phenotype comprises two components, the classical phenotype, corresponding to the "gene products," and a "genome phenotype," which is defined by the compositional constraints; and that natural selection plays a more important role in genome evolution than do random events. KW - hgt AU - Bernardi, G AU - Bernardi, G PY - 1986/// UR - http://view.ncbi.nlm.nih.gov/pubmed/3104608 ER -

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