A longitudinal study of an endemic disease in its wildlife reservoir: cowpox and wild rodents.

@article{citeulike:2550680, abstract = {Cowpox is an orthopoxvirus infection endemic in European wild rodents, but with a wide host range including human beings. In this longitudinal study we examined cowpox in two wild rodent species, bank voles Clethrionomys glareolus and wood mice Apodemus sylvaticus, to investigate the dynamics of a virus in its wild reservoir host. Trapping was carried out at 4-weekly intervals over 3 years and each animal caught was uniquely identified, blood sampled and tested for antibodies to cowpox. Antibody prevalence was higher in bank voles than in wood mice and seroconversion varied seasonally, with peaks in autumn. Infection was most common in males of both species but no clear association with age was demonstrated. This study provides a model for studying other zoonotic infections that derive from wild mammals since other approaches, such as one-off samples, will fail to detect the variation in infection and thus, risk to human health, demonstrated here.}, address = {Centre for Comparative Infectious Diseases, University of Liverpool.}, author = {Hazel, S. M. and Bennett, M. and Chantrey, J. and Bown, K. and Cavanagh, R. and Jones, T. R. and Baxby, D. and Begon, M. }, citeulike-article-id = {2550680}, issn = {0950-2688}, journal = {Epidemiol Infect}, keywords = {cowpox, endemic, longitudinal, orthopoxvirus, reservoir, rodent, serology}, month = {June}, number = {3}, pages = {551--562}, posted-at = {2008-03-18 11:52:12}, priority = {0}, title = {A longitudinal study of an endemic disease in its wildlife reservoir: cowpox and wild rodents.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10982080}, volume = {124}, year = {2000} }

TY - JOUR ID - citeulike:2550680 L3 - citeulike-article-id:2550680 TI - A longitudinal study of an endemic disease in its wildlife reservoir: cowpox and wild rodents. JF - Epidemiol Infect VL - 124 IS - 3 SP - 551 EP - 562 AD - Centre for Comparative Infectious Diseases, University of Liverpool. SN - 0950-2688 N2 - Cowpox is an orthopoxvirus infection endemic in European wild rodents, but with a wide host range including human beings. In this longitudinal study we examined cowpox in two wild rodent species, bank voles Clethrionomys glareolus and wood mice Apodemus sylvaticus, to investigate the dynamics of a virus in its wild reservoir host. Trapping was carried out at 4-weekly intervals over 3 years and each animal caught was uniquely identified, blood sampled and tested for antibodies to cowpox. Antibody prevalence was higher in bank voles than in wood mice and seroconversion varied seasonally, with peaks in autumn. Infection was most common in males of both species but no clear association with age was demonstrated. This study provides a model for studying other zoonotic infections that derive from wild mammals since other approaches, such as one-off samples, will fail to detect the variation in infection and thus, risk to human health, demonstrated here. KW - cowpox KW - endemic KW - longitudinal KW - orthopoxvirus KW - reservoir KW - rodent KW - serology AU - Hazel, SM AU - Bennett, M AU - Chantrey, J AU - Bown, K AU - Cavanagh, R AU - Jones, TR AU - Baxby, D AU - Begon, M PY - 2000/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/10982080 ER -