Activity in human ventral striatum locked to errors of reward prediction.

@article{citeulike:804182, abstract = {The mesolimbic dopaminergic system has long been known to be involved in the processing of rewarding stimuli, although recent evidence from animal research has suggested a more specific role of signaling errors in the prediction of rewards. We tested this hypothesis in humans, using functional magnetic resonance imaging (fMRI) and an operant conditioning paradigm for the discrete delivery of small quantities of fruit juice, along with a control experiment in which juice was substituted with a neutral visual stimulus. A local estimation of the activity in the ventral striatum showed a significant differentiation when the juice was withheld at the expected time of delivery; this finding was not replicated in the case of visual stimulation, providing evidence for time-locked processing of reward prediction errors in human ventral striatum.}, address = {Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA. gpagnon@emory.edu}, author = {Pagnoni, G. and Zink, C. F. and Montague, P. R. and Berns, G. S. }, citeulike-article-id = {804182}, doi = {10.1038/nn802}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {fmri, human, pg, reward, ventral\_striatum}, month = {February}, number = {2}, pages = {97--98}, posted-at = {2006-08-17 14:09:11}, priority = {2}, title = {Activity in human ventral striatum locked to errors of reward prediction.}, url = {http://dx.doi.org/10.1038/nn802}, volume = {5}, year = {2002} }

TY - JOUR ID - citeulike:804182 L3 - citeulike-article-id:804182 TI - Activity in human ventral striatum locked to errors of reward prediction. JF - Nat Neurosci VL - 5 IS - 2 SP - 97 EP - 98 AD - Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA. gpagnon@emory.edu SN - 1097-6256 N2 - The mesolimbic dopaminergic system has long been known to be involved in the processing of rewarding stimuli, although recent evidence from animal research has suggested a more specific role of signaling errors in the prediction of rewards. We tested this hypothesis in humans, using functional magnetic resonance imaging (fMRI) and an operant conditioning paradigm for the discrete delivery of small quantities of fruit juice, along with a control experiment in which juice was substituted with a neutral visual stimulus. A local estimation of the activity in the ventral striatum showed a significant differentiation when the juice was withheld at the expected time of delivery; this finding was not replicated in the case of visual stimulation, providing evidence for time-locked processing of reward prediction errors in human ventral striatum. KW - fmri KW - human KW - pg KW - reward KW - ventral_striatum AU - Pagnoni, G AU - Zink, CF AU - Montague, PR AU - Berns, GS PY - 2002/02// UR - http://dx.doi.org/10.1038/nn802 ER -