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kuhn library [212 articles]

Статьи, недавно добавленные в библиотеку kuhn library ordered by importance.
  • Compound library development guided by protein structure similarity clustering and natural product structure.
    Proc Natl Acad Sci U S A, Vol. 101, No. 48. (30 November 2004), pp. 16721-16726.
    by MA Koch, LO Wittenberg, S Basu, DA Jeyaraj, E Gourzoulidou, K Reinecke, A Odermatt, H Waldmann
    posted to design drug protein similarity by kuhn on 2006-01-20 08:36:18 as *****
  • Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways.
    J Am Chem Soc, Vol. 125, No. 39. (1 October 2003), pp. 11853-11865.
    by M Hattori, Y Okuno, S Goto, M Kanehisa
    posted to chemical metabolites structure by kuhn on 2005-09-09 16:16:12 as ***** along with 4 people BragilMassoud beapen alexg Evangelia
  • Metabolic Engineering in the -omics Era: Elucidating and Modulating Regulatory Networks.
    Microbiol Mol Biol Rev, Vol. 69, No. 2. (June 2005), pp. 197-216.
    by GN Vemuri, AA Aristidou
    posted to bioinformatics metabolites by kuhn on 2005-06-14 18:45:38 as *** along with 3 people and 1 group operon JeremyZucker athleem MetabolicModeling
  • Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.
    J Med Chem, Vol. 50, No. 25. (13 December 2007), pp. 6291-6294.
    by RE Martin, LG Green, W Guba, N Kratochwil, A Christ
    posted to drug drugdiscovery screening by kuhn on 2008-01-18 16:02:24 as **
  • Analysis of System Structure-Function Relationships
    ChemMedChem, Vol. 2, No. 12. (2007), pp. 1774-1782.
    by Anton F Fliri, William T Loging, Robert A Volkmann
    posted to activity_profile biospectra side_effects similarity by kuhn on 2008-01-18 13:21:14 as **
  • Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.
    Drug Discov Today, Vol. 10, No. 21. (1 November 2005), pp. 1421-1433.
    by S Whitebread, J Hamon, D Bojanic, L Urban
    posted to drug drugdiscovery review side_effects by kuhn on 2008-01-14 10:20:32 as **
  • From Astemizole to a Novel Hit Series of Small-Molecule Somatostatin 5 Receptor Antagonists via GPCR Affinity Profiling
    J. Med. Chem., Vol. 50, No. 25. (13 December 2007), pp. 6295-6298.
    by Wolfgang Guba, Luke G Green, Rainer E Martin, Olivier Roche, Nicole Kratochwil, Harald Mauser, Caterina Bissantz, Andreas Christ, Martin Stahl
    posted to activity_profile drugdiscovery gpcr by kuhn on 2008-01-11 13:24:18 as **
  • Predicting ADME properties and side effects: the BioPrint approach.
    Curr Opin Drug Discov Devel, Vol. 6, No. 4. (July 2003), pp. 470-480.
    by CM Krejsa, D Horvath, SL Rogalski, JE Penzotti, B Mao, F Barbosa, JC Migeon
    posted to biospectra drugdiscovery by kuhn on 2007-12-20 15:38:41 as **
  • Integrating high-content screening and ligand-target prediction to identify mechanism of action.
    Nat Chem Biol, Vol. 4, No. 1. (January 2008), pp. 59-68.
    by DW Young, A Bender, J Hoyt, E McWhinnie, GW Chirn, CY Tao, JA Tallarico, M Labow, JL Jenkins, TJ Mitchison, Y Feng
    posted to activity_profile drugdiscovery screening by kuhn on 2007-12-20 14:39:42 as ** along with 3 people Yanno jyuh kengg
  • The selectivity of protein kinase inhibitors: a further update.
    Biochem J, Vol. 408, No. 3. (15 December 2007), pp. 297-315.
    by J Bain, L Plater, M Elliott, N Shpiro, CJ Hastie, H McLauchlan, I Klevernic, JS Arthur, DR Alessi, P Cohen
    posted to activity_profile kinase by kuhn on 2007-12-20 14:38:09 as ** along with 2 people pbarker jyuh
  • Remediation of the protein data bank archive
    Nucl. Acids Res. (11 December 2007), gkm937.
    by Kim Henrick, Zukang Feng, Wolfgang F Bluhm, Dimitris Dimitropoulos, Jurgen F Doreleijers, Shuchismita Dutta, Judith L Flippen-Anderson, John Ionides, Chisa Kamada, Eugene Krissinel, Catherine L Lawson, John L Markley, Haruki Nakamura, Richard Newman, Yukiko Shimizu, Jawahar Swaminathan, Sameer Velankar, Jeramia Ory, Eldon L Ulrich, Wim Vranken, John Westbrook, Reiko Yamashita, Huanwang Yang, Jasmine Young, Muhammed Yousufuddin, Helen M Berman
    posted to database protein structure by kuhn on 2007-12-12 12:30:03 as **
  • New uses for old drugs
    Nature, Vol. 448, No. 7154. (08 August 2007), pp. 645-646.
    by Curtis R Chong, David J Sullivan
    posted to activity_profile drug drugdiscovery by kuhn on 2007-11-21 15:58:20 as **
  • Recognizing and exploiting differences between RNAi and small-molecule inhibitors
    Nat Chem Biol, Vol. 3, No. 12. (December 2007), pp. 739-744.
    by William A Weiss, Stephen S Taylor, Kevan M Shokat
    posted to kinase phenotype screening sirna by kuhn on 2007-11-19 14:01:13 as ** along with 1 person jyuh
  • A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
    Bioorganic & Medicinal Chemistry, Vol. 11, No. 20. (October 2003), pp. 4389-4415.
    by Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Kogen
    posted to drug drugdiscovery by kuhn on 2007-11-16 15:07:58 as **
  • Chemogenomics: an emerging strategy for rapid target and drug discovery
    Nat Rev Genet, Vol. 5, No. 4. (April 2004), pp. 262-275.
    by Markus Bredel, Edgar Jacoby
    posted to chemical drugdiscovery genomics by kuhn on 2007-10-23 16:35:24 as ** along with 1 person Yanno
  • Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors.
    J Med Chem, Vol. 49, No. 23. (16 November 2006), pp. 6802-6810.
    by JH Nettles, JL Jenkins, A Bender, Z Deng, JW Davies, M Glick
    posted to chemical similarity structure by kuhn on 2007-10-23 14:49:33 as ** along with 1 person tjimenez
  • A Novel Chemogenomics Knowledge-Based Ligand Design Strategy - Application to G Protein-Coupled Receptors
    Quantitative Structure-Activity Relationships, Vol. 20, No. 2. (2001), pp. 115-123.
    by Edgar Jacoby
    posted to drugdiscovery gpcr by kuhn on 2007-10-23 14:12:55 as **
  • Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Nat Biotech, Vol. 25, No. 9. (2007), pp. 1035-1044.
    by Marcus Bantscheff, Dirk Eberhard, Yann Abraham, Sonja Bastuck, Markus Boesche, Scott Hobson, Toby Mathieson, Jessica Perrin, Manfred Raida, Christina Rau, Valerie Reader, Gavain Sweetman, Andreas Bauer, Tewis Bouwmeester, Carsten Hopf, Ulrich Kruse, Gitte Neubauer, Nigel Ramsden, Jens Rick, Bernhard Kuster, Gerard Drewes
    posted to activity_profile drug kinase by kuhn on 2007-10-23 13:54:07 as ** along with 2 people jyuh apostola
  • A priori inference of cross reactivity for drug-targeted kinases.
    J Med Chem, Vol. 49, No. 11. (1 June 2006), pp. 3092-3100.
    by A Fernandez, S Maddipati
    posted to activity_profile drug kinase by kuhn on 2007-10-23 13:50:50 as ** along with 2 people BragilMassoud tjimenez
  • Systematic analysis of enzyme-catalyzed reaction patterns and prediction of microbial biodegradation pathways.
    J Chem Inf Model, Vol. 47, No. 4. (g 2007), pp. 1702-1712.
    by M Oh, T Yamada, M Hattori, S Goto, M Kanehisa
    posted to enzyme pathways reactions by kuhn on 2007-10-23 10:56:14 as **
  • The human disease network
    PNAS, Vol. 104, No. 21. (22 May 2007), pp. 8685-8690.
    by Kwang-Il Goh, Michael E Cusick, David Valle, Barton Childs, Marc Vidal, Albert-Laszlo Barabasi
    posted to disease interaction networks protein by kuhn on 2007-10-19 12:00:41 as ** along with 24 people and 8 groups yaredo shoshin carlk mingzhi Yanno jyuh aalibes cannin jfr yas balicea neveaire bundschu raiyar grahamc joepickrell leSyl henning dejori xingxu winterschlaefer naegele shikin nolodie GomezLab Biostatistics Computational-Genomics Bioinformatics Neuroscience steinmetzlab ic4 generif_paper
  • Complementarity between public and commercial databases: new opportunities in medicinal chemistry informatics.
    Curr Top Med Chem, Vol. 7, No. 15. (2007), pp. 1502-1508.
    by C Southan, P Várkonyi, S Muresan
    posted to chemical database by kuhn on 2007-10-02 17:14:08 as **
  • Chemical similarity searching
    JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, Vol. 38, No. 6. (1998), pp. 983-996.
    by P Willett, JM Barnard, GM Downs
    posted to chemical similarity by kuhn on 2007-09-12 13:46:00 as ** along with 1 person jerome
  • Acquired QT interval prolongation and HERG: implications for drug discovery and development.
    Eur J Pharmacol, Vol. 500, No. 1-3. (1 October 2004), pp. 129-142.
    by K Finlayson, HJ Witchel, J McCulloch, J Sharkey
    posted to drug side_effects by kuhn on 2007-09-03 16:00:25 as **
  • Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    Nature Reviews Drug Discovery, Vol. 6, No. 9., pp. 721-733.
    by Jürgen Wess, Richard M Eglen, Dinesh Gautam
    posted to drug drugdiscovery by kuhn on 2007-09-03 13:48:39 as ** along with 2 people and 2 groups jyuh dchughes G4ID Genetics-of-Gambling
  • Predicting undesirable drug interactions with promiscuous proteins in silico.
    Drug Discov Today, Vol. 9, No. 6. (15 March 2004), pp. 276-285.
    by S Ekins
    posted to drug interaction promiscuity protein side_effects by kuhn on 2007-08-20 09:59:55 as ** along with 2 people girschick tomb
  • Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
    Circulation, Vol. 102, No. 23. (5 December 2000), pp. 2836-2841.
    by Richard B Rothman, Michael H Baumann, Jason E Savage, Laura Rauser, Ace Mcbride, Sandra J Hufeisen, Bryan L Roth
    posted to drug side_effects by kuhn on 2007-08-20 09:54:01 as **
  • Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure
    ChemMedChem, Vol. 2, No. 6. (2007), pp. 861-873.
    by Andreas Bender, Josef Scheiber, Meir Glick, John w, Kamal Azzaoui, Jacques Hamon, Laszlo Urban, Steven Whitebread, Jeremy l
    posted to drug p pharmacology prediction side_effects by kuhn on 2007-08-17 14:53:36 as ** along with 1 person apostola
  • Comparing classical pathways and modern networks: towards the development of an edge ontology
    Trends in Biochemical Sciences, Vol. In Press, Corrected Proof
    by Long J Lu, Andrea Sboner, Yuanpeng J Huang, Hao X Lu, Tara A Gianoulis, Kevin Y Yip, Philip M Kim, Gaetano T Montelione, Mark B Gerstein
    posted to interaction networks pathways by kuhn on 2007-08-08 09:15:02 as ** along with 3 people lenov thomaskelder andrawaagmeester
  • Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels.
    J Pharmacol Exp Ther, Vol. 314, No. 3. (September 2005), pp. 961-971.
    by HS Chen, SA Lipton
    posted to drug interaction protein by kuhn on 2007-08-08 09:10:37 as **
  • Neural computing in cancer drug development: predicting mechanism of action
    Science, Vol. 258, No. 5081. (16 October 1992), pp. 447-451.
    by Jn Weinstein, Kw Kohn, Mr Grever, Vn Viswanadhan, Lv Rubinstein, Ap Monks, Da Scudiero, L Welch, Ad Koutsoukos, Aj Chiausa, Al Et
    posted to cancer machine_learning by kuhn on 2007-08-08 09:01:25 as **
  • NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.
    Nucleic Acids Res, Vol. 35, No. Database issue. (January 2007)
    by KD Pruitt, T Tatusova, DR Maglott
    posted to database protein by kuhn on 2007-08-08 08:39:02 as ** along with 4 people and 1 group ninch jjray indigoviolet incovoma EisenLab
  • Ensembl 2007.
    Nucleic Acids Res, Vol. 35, No. Database issue. (January 2007)
    by TJ Hubbard, BL Aken, K Beal, B Ballester, M Caccamo, Y Chen, L Clarke, G Coates, F Cunningham, T Cutts, T Down, SC Dyer, S Fitzgerald, J Fernandez-Banet, S Graf, S Haider, M Hammond, J Herrero, R Holland, K Howe, K Howe, N Johnson, A Kahari, D Keefe, F Kokocinski, E Kulesha, D Lawson, I Longden, C Melsopp, K Megy, P Meidl, B Ouverdin, A Parker, A Prlic, S Rice, D Rios, M Schuster, I Sealy, J Severin, G Slater, D Smedley, G Spudich, S Trevanion, A Vilella, J Vogel, S White, M Wood, T Cox, V Curwen, R Durbin, XM Fernandez-Suarez, P Flicek, A Kasprzyk, G Proctor, S Searle, J Smith, A Ureta-Vidal, E Birney
    posted to database protein by kuhn on 2007-08-08 08:36:08 as ** along with 8 people and 1 group skumagai dullhunk massivemayhem incovoma Garamonfok asddd loopback007 flexer Cancer_Stem_Cells
  • Representations of molecular pathways: an evaluation of SBML, PSI MI and BioPAX
    Bioinformatics, Vol. 21, No. 24. (15 December 2005), pp. 4401-4407.
    by Lena Stromback, Patrick Lambrix
    posted to bioinformatics pathways tool by kuhn on 2007-08-07 15:36:00 as ** along with 3 people and 2 groups balajis wnpx dagmar dIEMoSIRIS compneur
  • Extraction of regulatory gene/protein networks from Medline.
    Bioinformatics (26 July 2005)
    by Jasmin Saric, Lars Juhl J Jensen, Rossitza Ouzounova, Isabel Rojas, Peer Bork
    posted to textmining by kuhn on 2007-08-07 15:27:35 as ** along with 4 people and 1 group balajis caporaso helliontroy larsjuhljensen biomedical-nlp
  • Recent developments of the chemistry development kit (CDK) - an open-source java library for chemo- and bioinformatics.
    Curr Pharm Des, Vol. 12, No. 17. (2006), pp. 2111-2120.
    by C Steinbeck, C Hoppe, S Kuhn, M Floris, R Guha, EL Willighagen
    posted to chemical similarity tool by kuhn on 2007-08-07 15:27:05 as ** along with 2 people egonw noby
  • Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide.
    Chirality, Vol. 7, No. 1. (1995), pp. 44-52.
    by T Eriksson, S Björkman, B Roth, A Fyge, P Höglund
    posted to drug pharmacology by kuhn on 2007-08-07 15:24:59 as **
  • Reactome: a knowledgebase of biological pathways.
    Nucleic Acids Res, Vol. 33, No. Database issue. (1 January 2005)
    by G Joshi-Tope, M Gillespie, I Vastrik, P D'Eustachio, E Schmidt, B de Bono, B Jassal, GR Gopinath, GR Wu, L Matthews, S Lewis, E Birney, L Stein
    posted to database pathways by kuhn on 2007-08-07 15:20:35 as ** along with 8 people and 1 group jyuh aalibes yas dullhunk duartemolha massivemayhem cerami yggdrasil T_lab
  • MetaCyc: a multiorganism database of metabolic pathways and enzymes.
    Nucleic Acids Res, Vol. 34, No. Database issue. (1 January 2006)
    by R Caspi, H Foerster, CA Fulcher, R Hopkinson, J Ingraham, P Kaipa, M Krummenacker, S Paley, J Pick, SY Rhee, C Tissier, P Zhang, PD Karp
    posted to database pathways by kuhn on 2007-08-07 15:17:17 as ** along with 1 person and 1 group jberro Projet_ENSIMAG
  • ChemDB Update - Full-Text Search and Virtual Chemical Space.
    Bioinformatics (28 June 2007)
    by Jonathan H H Chen, Erik Linstead, S Joshua J Swamidass, Dennis Wang, Pierre Baldi
    posted to chemical database by kuhn on 2007-08-07 15:11:41 as ** along with 3 people jyuh massivemayhem baldigroup
  • Database resources of the National Center for Biotechnology Information.
    Nucleic Acids Res, Vol. 35, No. Database issue. (January 2007)
    by DL Wheeler, T Barrett, DA Benson, SH Bryant, K Canese, V Chetvernin, DM Church, M DiCuccio, R Edgar, S Federhen, LY Geer, Y Kapustin, O Khovayko, D Landsman, DJ Lipman, TL Madden, DR Maglott, J Ostell, V Miller, KD Pruitt, GD Schuler, E Sequeira, ST Sherry, K Sirotkin, A Souvorov, G Starchenko, RL Tatusov, TA Tatusova, L Wagner, E Yaschenko
    posted to chemical database by kuhn on 2007-08-07 15:09:23 as ** along with 5 people and 1 group cyrille balajis dullhunk cat_worth Gaetan structural_bioinformatics
  • A Cheminformatic Toolkit for Mining Biomedical Knowledge.
    Pharm Res (24 March 2007)
    by Gus R Rosania, Gordon Crippen, Peter Woolf, David States, Kerby Shedden
    posted to chemical database interaction by kuhn on 2007-07-26 12:31:29 as ** along with 1 person jyuh
  • Large-Scale Annotation of Small-Molecule Libraries Using Public Databases.
    J Chem Inf Model (3 July 2007)
    by Yingyao Zhou, Bin Zhou, Kaisheng Chen, S F Yan, Frederick J King, Shumei Jiang, Elizabeth A Winzeler
    posted to chemical database interaction by kuhn on 2007-07-26 12:31:15 as **
  • Elucidating mechanisms of drug-induced toxicity
    Nature Reviews Drug Discovery, Vol. 4, No. 5. (01 May 2005), pp. 410-420.
    by Daniel C Liebler, Peter P Guengerich
    posted to drug review side_effects by kuhn on 2007-07-23 10:17:03 as **
  • Six-fold speed-up of Smith-Waterman sequence database searches using parallel processing on common microprocessors.
    Bioinformatics, Vol. 16, No. 8. (August 2000), pp. 699-706.
    by T Rognes, E Seeberg
    posted to alignment protein by kuhn on 2007-07-11 08:39:06 as ** along with 1 person jofiel
  • Nifedipine enhances amoxicillin absorption kinetics and bioavailability in humans.
    J Pharmacol Exp Ther, Vol. 255, No. 1. (October 1990), pp. 312-317.
    by JF Westphal, JH Trouvin, A Deslandes, C Carbon
    posted to drug interaction by kuhn on 2007-07-09 13:33:51 as **
  • The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?
    Neuroscientist, Vol. 6, No. 4. (1 August 2000), pp. 252-262.
    by Brian L Roth, Estelle Lopez, Shamil Patel, Wesley K Kroeze
    posted to chemical database protein by kuhn on 2007-06-09 09:33:43 as **
  • Error bars in experimental biology
    J. Cell Biol., Vol. 177, No. 1. (9 April 2007), pp. 7-11.
    by Geoff Cumming, Fiona Fidler, David L Vaux
    posted to review statistics by kuhn on 2007-06-06 14:39:53 as ** along with 32 people and 5 groups mjoach arindrartow jyuh brian ana batallah manduca Borelli dayjm kristina chad_davis tny dullhunk rabu lechristophe nelmor jdelcampo fishtank emmahe lisa1 Daria_G devender bmaust cabbagezs natstreet winterschlaefer krokicki loopback007 wilbur tdmckee renatomilani delenca structural_bioinformatics Bioinformatics VisionLab FlowCytometry Microbial-Ecology
  • The relationship between the sequence identities of alpha helical proteins in the PDB and the molecular similarities of their ligands.
    J Chem Inf Comput Sci, Vol. 41, No. 6. (c 2001), pp. 1617-1622.
    by JB Mitchell
    posted to chemical pdb protein similarity structure by kuhn on 2007-06-06 13:44:13 as **
  • Prediction of missing enzyme genes in a bacterial metabolic network: Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa
    FEBS Journal, Vol. 274, No. 9. (May 2007), pp. 2262-2273.
    by Yamanishi, Yoshihiro, Mihara, Hisaaki, Osaki, Motoharu, Muramatsu, Hisashi, Esaki, Nobuyoshi, Sato, Tetsuya, Hizukuri, Yoshiyuki, Goto, Susumu, Kanehisa, Minoru
    posted to chemical pathways prediction by kuhn on 2007-06-05 08:53:55 as ** along with 2 people cdallett shung
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