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kuhn drug [59 articles]

Recent papers added to kuhn library classified by the tag drug. You can also see everyone's drug.
  • Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.
    J Med Chem, Vol. 50, No. 25. (13 December 2007), pp. 6291-6294.
    by RE Martin, LG Green, W Guba, N Kratochwil, A Christ
    posted to drug drugdiscovery screening by kuhn on 2008-01-18 16:02:24 as **
  • Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development.
    Drug Discov Today, Vol. 10, No. 21. (1 November 2005), pp. 1421-1433.
    by S Whitebread, J Hamon, D Bojanic, L Urban
    posted to drug drugdiscovery review side_effects by kuhn on 2008-01-14 10:20:32 as **
  • New uses for old drugs
    Nature, Vol. 448, No. 7154. (08 August 2007), pp. 645-646.
    by Curtis R Chong, David J Sullivan
    posted to activity_profile drug drugdiscovery by kuhn on 2007-11-21 15:58:20 as **
  • A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
    Bioorganic & Medicinal Chemistry, Vol. 11, No. 20. (October 2003), pp. 4389-4415.
    by Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Kogen
    posted to drug drugdiscovery by kuhn on 2007-11-16 15:07:58 as **
  • Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Nat Biotech, Vol. 25, No. 9. (2007), pp. 1035-1044.
    by Marcus Bantscheff, Dirk Eberhard, Yann Abraham, Sonja Bastuck, Markus Boesche, Scott Hobson, Toby Mathieson, Jessica Perrin, Manfred Raida, Christina Rau, Valerie Reader, Gavain Sweetman, Andreas Bauer, Tewis Bouwmeester, Carsten Hopf, Ulrich Kruse, Gitte Neubauer, Nigel Ramsden, Jens Rick, Bernhard Kuster, Gerard Drewes
    posted to activity_profile drug kinase by kuhn on 2007-10-23 13:54:07 as ** along with 2 people jyuh apostola
  • A priori inference of cross reactivity for drug-targeted kinases.
    J Med Chem, Vol. 49, No. 11. (1 June 2006), pp. 3092-3100.
    by A Fernandez, S Maddipati
    posted to activity_profile drug kinase by kuhn on 2007-10-23 13:50:50 as ** along with 2 people BragilMassoud tjimenez
  • Acquired QT interval prolongation and HERG: implications for drug discovery and development.
    Eur J Pharmacol, Vol. 500, No. 1-3. (1 October 2004), pp. 129-142.
    by K Finlayson, HJ Witchel, J McCulloch, J Sharkey
    posted to drug side_effects by kuhn on 2007-09-03 16:00:25 as **
  • Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    Nature Reviews Drug Discovery, Vol. 6, No. 9., pp. 721-733.
    by Jürgen Wess, Richard M Eglen, Dinesh Gautam
    posted to drug drugdiscovery by kuhn on 2007-09-03 13:48:39 as ** along with 2 people and 2 groups jyuh dchughes G4ID Genetics-of-Gambling
  • Predicting undesirable drug interactions with promiscuous proteins in silico.
    Drug Discov Today, Vol. 9, No. 6. (15 March 2004), pp. 276-285.
    by S Ekins
    posted to drug interaction promiscuity protein side_effects by kuhn on 2007-08-20 09:59:55 as ** along with 2 people tomb girschick
  • Evidence for Possible Involvement of 5-HT2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
    Circulation, Vol. 102, No. 23. (5 December 2000), pp. 2836-2841.
    by Richard B Rothman, Michael H Baumann, Jason E Savage, Laura Rauser, Ace Mcbride, Sandra J Hufeisen, Bryan L Roth
    posted to drug side_effects by kuhn on 2007-08-20 09:54:01 as **
  • Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure
    ChemMedChem, Vol. 2, No. 6. (2007), pp. 861-873.
    by Andreas Bender, Josef Scheiber, Meir Glick, John w, Kamal Azzaoui, Jacques Hamon, Laszlo Urban, Steven Whitebread, Jeremy l
    posted to drug p pharmacology prediction side_effects by kuhn on 2007-08-17 14:53:36 as ** along with 1 person apostola
  • Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels.
    J Pharmacol Exp Ther, Vol. 314, No. 3. (September 2005), pp. 961-971.
    by HS Chen, SA Lipton
    posted to drug interaction protein by kuhn on 2007-08-08 09:10:37 as **
  • Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide.
    Chirality, Vol. 7, No. 1. (1995), pp. 44-52.
    by T Eriksson, S Björkman, B Roth, A Fyge, P Höglund
    posted to drug pharmacology by kuhn on 2007-08-07 15:24:59 as **
  • Elucidating mechanisms of drug-induced toxicity
    Nature Reviews Drug Discovery, Vol. 4, No. 5. (01 May 2005), pp. 410-420.
    by Daniel C Liebler, Peter P Guengerich
    posted to drug review side_effects by kuhn on 2007-07-23 10:17:03 as **
  • Nifedipine enhances amoxicillin absorption kinetics and bioavailability in humans.
    J Pharmacol Exp Ther, Vol. 255, No. 1. (October 1990), pp. 312-317.
    by JF Westphal, JH Trouvin, A Deslandes, C Carbon
    posted to drug interaction by kuhn on 2007-07-09 13:33:51 as **
  • When good drugs go bad
    Nature, Vol. 446, No. 7139. (25 April 2007), pp. 975-977.
    by Kathleen M Giacomini, Ronald M Krauss, Dan M Roden, Michel Eichelbaum, Michael R Hayden, Yusuke Nakamura
    posted to drug p side_effects by kuhn on 2007-06-12 16:23:20 as read
  • The Many Roles of Computation in Drug Discovery
    Science, Vol. 303, No. 5665. (19 March 2004), pp. 1813-1818.
    by William L Jorgensen
    posted to drug drugdiscovery review by kuhn on 2007-05-16 10:10:30 as ** along with 8 people dgruiz balicea blackbart ramensky euan junehlee onufriev ashaytan
  • Role of prostacyclin in the cardiovascular response to thromboxane A2.
    Science, Vol. 296, No. 5567. (19 April 2002), pp. 539-541.
    by Y Cheng, SC Austin, B Rocca, BH Koller, TM Coffman, T Grosser, JA Lawson, GA FitzGerald
    posted to drug side_effects by kuhn on 2007-05-04 09:54:39 as **
  • Sildenafil (Viagra) and ophthalmology.
    Surv Ophthalmol, Vol. 44, No. 2. (t 1999), pp. 153-162.
    by MF Marmor, R Kessler
    posted to drug side_effects by kuhn on 2007-05-04 09:31:14 as *
  • Drugs, their targets and the nature and number of drug targets
    Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834.
    by Peter Imming, Christian Sinning, Achim Meyer
    posted to drug p review by kuhn on 2007-05-02 10:26:01 as ** along with 4 people and 1 group xdeupi massivemayhem Ao_Li2007 yaredo LabCompMed
  • Relating protein pharmacology by ligand chemistry
    Nature Biotechnology, Vol. 25, No. 2. (07 February 2007), pp. 197-206.
    by Michael J Keiser, Bryan L Roth, Blaine N Armbruster, Paul Ernsberger, John J Irwin, Brian K Shoichet
    posted to drug drugdiscovery p prediction similarity by kuhn on 2007-02-16 14:15:57 as ** along with 7 people ucbcjbm Yanno tjimenez daevans massivemayhem dgront jerome_ucsf_slb
  • Knowledge and Intelligence in Drug Design
    Annual Reports in Medicinal Chemistry, Vol. 41 (2006), pp. 425-437.
    by Andrew L Hopkins, Alex Polinsky
    posted to chemical drug drugdiscovery by kuhn on 2007-02-12 10:39:07 as ** along with 3 people MarcoAlvarez hkreysa kevinchannon
  • How many drug targets are there?
    Nature Reviews Drug Discovery, Vol. 5, No. 12., pp. 993-996.
    by John P Overington, Bissan Al-Lazikani, Andrew L Hopkins
    posted to drug drugdiscovery review by kuhn on 2006-12-04 09:31:29 as read along with 10 people and 1 group BragilMassoud cannin bicko mingzhi higueruelo srp33 ramensky aheilbut gemmalholliday ajaymalik libr
  • The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
    Science, Vol. 313, No. 5795. (29 September 2006), pp. 1929-1935.
    by J Lamb, ED Crawford, D Peck, JW Modell, IC Blat, MJ Wrobel, J Lerner, JP Brunet, A Subramanian, KN Ross, M Reich, H Hieronymus, G Wei, SA Armstrong, SJ Haggarty, PA Clemons, R Wei, SA Carr, ES Lander, TR Golub
    posted to activity_profile bioassay chemical drug microarray by kuhn on 2006-10-02 09:35:58 as ** along with 22 people and 9 groups dansullivanblk BragilMassoud jyuh jfr yas balajis marcius lhonigberg neveaire kengg ealloza koller mlovell jdiggans ezra jeremymiller frohike massivemayhem lp2 pablomendes jdiezperezj askrajiv Biostatistics Computational-Genomics Bioinformatics Neuroscience T_lab BioinfoCIPF SGU-CIPF GeschwindLab Plantandetc
  • Characteristic physical properties and structural fragments of marketed oral drugs.
    J Med Chem, Vol. 47, No. 1. (1 January 2004), pp. 224-232.
    by M Vieth, MG Siegel, RE Higgs, IA Watson, DH Robertson, KA Savin, GL Durst, PA Hipskind
    posted to drug history by kuhn on 2006-09-29 14:33:41 as **
  • The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (Annual)
    by Merck
    posted to chemical drug by kuhn on 2006-07-27 16:01:53 as *
  • Global mapping of pharmacological space
    Nature Biotechnology, Vol. 24, No. 7. (13 July 2006), pp. 805-815.
    by Gaia V Paolini, Richard HB Shapland, Willem P van Hoorn, Jonathan S Mason, Andrew L Hopkins
    posted to activity_profile drug networks promiscuity ruleof5 by kuhn on 2006-07-17 09:44:52 as read along with 7 people and 1 group Yanno BragilMassoud jyuh bicko caporaso allmensch jerome_ucsf_slb biomedical-nlp
  • notes Classification of kinase inhibitors using a Bayesian model.
    J Med Chem, Vol. 47, No. 18. (26 August 2004), pp. 4463-4470.
    by X Xia, EG Maliski, P Gallant, D Rogers
    posted to drug kinase prediction statistics by kuhn on 2006-07-17 09:37:52 as ** along with 3 people jerome LamBras thanatos
  • An information-intensive approach to the molecular pharmacology of cancer.
    Science, Vol. 275, No. 5298. (17 January 1997), pp. 343-349.
    by JN Weinstein, TG Myers, PM O'Connor, SH Friend, AJ Fornace, KW Kohn, T Fojo, SE Bates, LV Rubinstein, NL Anderson, JK Buolamwini, WW van Osdol, AP Monks, DA Scudiero, EA Sausville, DW Zaharevitz, B Bunow, VN Viswanadhan, GS Johnson, RE Wittes, KD Paull
    posted to bioassay cancer clustering drug drugdiscovery by kuhn on 2006-06-27 12:53:59 as ** along with 1 person textoris
  • notes Dependence of Molecular Properties on Proteomic Family for Marketed Oral Drugs
    J. Med. Chem. (13 May 2006)
    by M Vieth, JJ Sutherland
    posted to chemical drug pharmacology ruleof5 by kuhn on 2006-06-02 08:32:45 as **
  • notes Identifying off-target effects and hidden phenotypes of drugs in human cells
    Nat Chem Biol, Vol. 2, No. 6. (June 2006), pp. 329-337.
    by Marnie L Macdonald, Jane Lamerdin, Stephen Owens, Brigitte H Keon, Graham K Bilter, Zhidi Shang, Zhengping Huang, Helen Yu, Jennifer Dias, Tomoe Minami, Stephen W Michnick, John K Westwick
    posted to drug drugdiscovery phenotype prediction by kuhn on 2006-06-02 08:28:14 as read
  • The druggable genome.
    Nat Rev Drug Discov, Vol. 1, No. 9. (September 2002), pp. 727-730.
    by AL Hopkins, CR Groom
    posted to drug genes genetics history p by kuhn on 2006-05-26 10:13:10 as ** along with 5 people and 1 group apostola dullhunk caporaso higueruelo thanatos biomedical-nlp
  • Drug trials: Stacking the deck
    Nature, Vol. 440, No. 7082. (15 March 2006), pp. 270-272.
    by Jim Giles
    posted to bias clinical_trials design drug by kuhn on 2006-03-16 10:49:18 as read
  • Incomplete protein packing as a selectivity filter in drug design.
    Structure, Vol. 13, No. 12. (December 2005), pp. 1829-1836.
    by A Fernández
    posted to design drug structure by kuhn on 2006-02-28 11:39:39 as ** along with 1 person BragilMassoud
  • Registering clinical trials.
    JAMA, Vol. 290, No. 4. (23 July 2003), pp. 516-523.
    by K Dickersin, D Rennie
    posted to clinical_trials database drug by kuhn on 2006-02-28 10:58:28 as ** along with 1 person wandall
  • Functional genomics to new drug targets.
    Nat Rev Drug Discov, Vol. 3, No. 11. (November 2004), pp. 965-972.
    by R Kramer, D Cohen
    posted to drug genomics by kuhn on 2006-02-14 16:09:22 as ** along with 1 person BragilMassoud
  • Biological spectra analysis: Linking biological activity profiles to molecular structure
    PNAS, Vol. 102, No. 2. (11 January 2005), pp. 261-266.
    by Anton F Fliri, William T Loging, Peter F Thadeio, Robert A Volkmann
    posted to activity_profile biospectra drug structure by kuhn on 2006-02-14 12:55:16 as **
  • Analysis of drug-induced effect patterns to link structure and side effects of medicines
    Nat Chem Biol, Vol. 1, No. 7. (December 2005), pp. 389-397.
    by Anton F Fliri, William T Loging, Peter F Thadeio, Robert A Volkmann
    posted to drug p side_effects structure by kuhn on 2006-02-14 12:36:12 as **
  • Can we rationally design promiscuous drugs?
    Curr Opin Struct Biol (24 January 2006)
    by Andrew L L Hopkins, Jonathan S S Mason, John P P Overington
    posted to drug drugdiscovery promiscuity by kuhn on 2006-02-14 12:25:01 as ** along with 6 people and 1 group BragilMassoud apaydin bicko yongzhao ramensky aheilbut TSRI_MGL
  • Illuminating drug discovery with biological pathways.
    FEBS Lett, Vol. 579, No. 8. (21 March 2005), pp. 1872-1877.
    by G Apic, T Ignjatovic, S Boyer, RB Russell
    posted to drug drugdiscovery pathways side_effects systemsbiology by kuhn on 2006-02-08 14:37:32 as ** along with 5 people Borelli chad_davis wnpx mikaelhuss renatomilani
  • Early prediction of drug metabolism and toxicity: systems biology approach and modeling.
    Drug Discov Today, Vol. 9, No. 3. (1 February 2004), pp. 127-135.
    by A Bugrim, T Nikolskaya, Y Nikolsky
    posted to drug metabolites systemsbiology by kuhn on 2006-02-08 12:51:59 as ** along with 1 person shikin
  • The druggable genome: an update.
    Drug Discov Today, Vol. 10, No. 23-24. (December 2005), pp. 1607-1610.
    by AP Russ, S Lampel
    posted to drug genes genetics by kuhn on 2006-01-25 13:32:16 as ** along with 5 people and 3 groups ucbcjbm Yanno marcius eweaver caporaso biomedical-nlp BioinfoCIPF SGU-CIPF
  • Lessons from natural molecules
    Nature, Vol. 432, No. 7019. (16 December 2004), pp. 829-837.
    by Jon Clardy, Christopher Walsh
    posted to drug natural_molecule review by kuhn on 2006-01-23 14:09:24 as ** along with 1 person Yanno
  • Knockouts model the 100 best-selling drugs--will they model the next 100?
    Nat Rev Drug Discov, Vol. 2, No. 1. (January 2003), pp. 38-51.
    by BP Zambrowicz, AT Sands
    posted to drug genetics by kuhn on 2006-01-23 14:03:52 as ** along with 2 people jeremymiller thanatos
  • Chemical space and biology
    Nature, Vol. 432, No. 7019. (16 December 2004), pp. 824-828.
    by Christopher M Dobson
    posted to chemical drug review by kuhn on 2006-01-23 13:44:18 as ** along with 2 people and 3 groups marcius caporaso biomedical-nlp BioinfoCIPF SGU-CIPF
  • Systems and integrative biology as alternative guises for pharmacology: prime time for an iPharm concept?
    Biochem Pharmacol, Vol. 70, No. 12. (5 December 2005), pp. 1707-1716.
    by M Williams
    posted to drug pharmacology systemsbiology by kuhn on 2006-01-20 13:29:30 as **
  • A small molecule–kinase interaction map for clinical kinase inhibitors
    Nature Biotechnology, Vol. 23, No. 3. (13 February 2005), pp. 329-336.
    by Miles A Fabian, William H Biggs, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne M Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart
    posted to drug interaction kinase by kuhn on 2006-01-20 10:56:20 as ** along with 6 people Yanno BragilMassoud tjimenez 7ofAnn seowu hchmani
  • Classifying "kinase inhibitor-likeness" by using machine-learning methods.
    Chembiochem, Vol. 6, No. 3. (March 2005), pp. 558-566.
    by H Briem, J Günther
    posted to drug kinase machine_learning similarity by kuhn on 2006-01-20 10:52:59 as read along with 2 people ucbcjbm hans228klavier
  • Compound library development guided by protein structure similarity clustering and natural product structure.
    Proc Natl Acad Sci U S A, Vol. 101, No. 48. (30 November 2004), pp. 16721-16726.
    by MA Koch, LO Wittenberg, S Basu, DA Jeyaraj, E Gourzoulidou, K Reinecke, A Odermatt, H Waldmann
    posted to design drug protein similarity by kuhn on 2006-01-20 08:36:18 as *****
  • Natural products as sources of new drugs over the period 1981-2002.
    J Nat Prod, Vol. 66, No. 7. (July 2003), pp. 1022-1037.
    by DJ Newman, GM Cragg, KM Snader
    posted to design drug natural_products by kuhn on 2006-01-20 08:35:29 as ** along with 1 person dkanter
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