Bioactivity in glass/PMMA composites used as drug delivery system

by: D Arcos, CV Ragel, M Vallet-Regí

Biomaterials, Vol. 22, No. 7. (April 2001), pp. 701-708.

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bone, composites, drug_delivery, gentamicin, hydroxyapatite, pmma

Abstract

Gentamicin sulfate has been incorporated in composites prepared from a SiO2-CaO-P2O5 bioactive glass and polymethylmethacrylate. Data showed that these materials could be used as drug delivery system, keeping the bioactive behavior of the glass. The composites supply high doses of the antibiotic during the first hours when they are soaked in simulated body fluid (SBF). Thereafter, a slower drug release is produced, supplying [`]maintenance' doses until the end of the experiment. The gentamicin release rate is related with the ionic Ca2+ and H3O+ exchange between composite and SBF. The porous structure of the composites allows the growth of hydroxycarbonate apatite on the surface and into the pores.

@article{citeulike:2813557, abstract = {Gentamicin sulfate has been incorporated in composites prepared from a SiO2-CaO-P2O5 bioactive glass and polymethylmethacrylate. Data showed that these materials could be used as drug delivery system, keeping the bioactive behavior of the glass. The composites supply high doses of the antibiotic during the first hours when they are soaked in simulated body fluid (SBF). Thereafter, a slower drug release is produced, supplying [`]maintenance' doses until the end of the experiment. The gentamicin release rate is related with the ionic Ca2+ and H3O+ exchange between composite and SBF. The porous structure of the composites allows the growth of hydroxycarbonate apatite on the surface and into the pores.}, author = {Arcos, D. and Ragel, C. V. and Vallet-Reg\'{i}, M. }, citeulike-article-id = {2813557}, doi = {10.1016/S0142-9612(00)00233-7}, journal = {Biomaterials}, keywords = {bone, composites, drug\_delivery, gentamicin, hydroxyapatite, pmma}, month = {April}, number = {7}, pages = {701--708}, posted-at = {2008-05-19 17:20:25}, priority = {2}, title = {Bioactivity in glass/PMMA composites used as drug delivery system}, url = {http://dx.doi.org/10.1016/S0142-9612(00)00233-7}, volume = {22}, year = {2001} }

RIS record

TY - JOUR ID - citeulike:2813557 L3 - citeulike-article-id:2813557 TI - Bioactivity in glass/PMMA composites used as drug delivery system JF - Biomaterials VL - 22 IS - 7 SP - 701 EP - 708 N2 - Gentamicin sulfate has been incorporated in composites prepared from a SiO2-CaO-P2O5 bioactive glass and polymethylmethacrylate. Data showed that these materials could be used as drug delivery system, keeping the bioactive behavior of the glass. The composites supply high doses of the antibiotic during the first hours when they are soaked in simulated body fluid (SBF). Thereafter, a slower drug release is produced, supplying [`]maintenance' doses until the end of the experiment. The gentamicin release rate is related with the ionic Ca2+ and H3O+ exchange between composite and SBF. The porous structure of the composites allows the growth of hydroxycarbonate apatite on the surface and into the pores. KW - bone KW - composites KW - drug_delivery KW - gentamicin KW - hydroxyapatite KW - pmma AU - Arcos, D AU - Ragel, CV AU - Vallet-Regí, M PY - 2001/04// UR - http://dx.doi.org/10.1016/S0142-9612(00)00233-7 ER -

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