Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.

@article{citeulike:81506, abstract = {Genetic variation of HIV-1 represents a major obstacle for AIDS vaccine development. With the amino acid sequence divergence as high as 30\% in envelopes between different subtypes among HIV-1 group M viruses, it is unlikely that cross-subtype protection will occur equally well among all subtypes. Computer programs have been used to generate 'centralized' HIV gene sequences: consensus, ancestor or center of the tree. These sequences can decrease the genetic distances between the 'centralized' and wild-type gene immunogens to half of those between any wild-type immuongens to each other. Recent studies demonstrated that an artificial group M consensus env gene is equidistant from any subtype and recombinants. It is biologically functional and preserves antigenicity similar to contemporary Env proteins. Most importantly, the group M consensus Env immunogen can elicit both T- and B-cell responses to wild-type HIV-1 isolates.}, address = {The Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. gao00006@mc.duke.edu}, author = {Gao, F. and Korber, B. T. and Weaver, E. and Liao, H. X. and Hahn, B. H. and Haynes, B. F. }, citeulike-article-id = {81506}, issn = {1476-0584}, journal = {Expert Rev Vaccines}, keywords = {hiv}, month = {August}, number = {4 Suppl}, posted-at = {2005-01-21 16:08:07}, priority = {2}, title = {Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15285714}, volume = {3}, year = {2004} }

TY - JOUR ID - citeulike:81506 L3 - citeulike-article-id:81506 TI - Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity. JF - Expert Rev Vaccines VL - 3 IS - 4 Suppl AD - The Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA. gao00006@mc.duke.edu SN - 1476-0584 N2 - Genetic variation of HIV-1 represents a major obstacle for AIDS vaccine development. With the amino acid sequence divergence as high as 30% in envelopes between different subtypes among HIV-1 group M viruses, it is unlikely that cross-subtype protection will occur equally well among all subtypes. Computer programs have been used to generate 'centralized' HIV gene sequences: consensus, ancestor or center of the tree. These sequences can decrease the genetic distances between the 'centralized' and wild-type gene immunogens to half of those between any wild-type immuongens to each other. Recent studies demonstrated that an artificial group M consensus env gene is equidistant from any subtype and recombinants. It is biologically functional and preserves antigenicity similar to contemporary Env proteins. Most importantly, the group M consensus Env immunogen can elicit both T- and B-cell responses to wild-type HIV-1 isolates. KW - hiv AU - Gao, F AU - Korber, BT AU - Weaver, E AU - Liao, HX AU - Hahn, BH AU - Haynes, BF PY - 2004/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/15285714 ER -