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neils article-predikin [51 articles]

Recent papers added to neils library classified by the tag article-predikin. You can also see everyone's article-predikin.
  • Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.
    Nucleic Acids Res, Vol. 31, No. 13. (1 July 2003), pp. 3635-3641.
    by JC Obenauer, LC Cantley, MB Yaffe
    posted to algorithm database amino-acid transduction structure software sites signal sequence proteome protein phosphorylation motifs internet binding article-predikin article-nar analysis by neils on 2008-04-24 16:16:06 as ** along with 2 people Evangelia mloewer
  • Identification of Phosphorylation Sites in Protein Kinase A Substrates Using Artificial Neural Networks and Mass Spectrometry
    J. Proteome Res., Vol. 3, No. 3. (14 June 2004), pp. 426-433.
    by M Hjerrild, A Stensballe, TE Rasmussen, CB Kofoed, N Blom, T Sicheritz-Ponten, MR Larsen, S Brunak, ON Jensen, S Gammeltoft
    posted to mass-spec article-predikin bioinformatics netphosk neural-network phosphorylation prediction by neils on 2008-04-16 04:05:30 as **
  • Protein kinase specificity. A strategic collaboration between kinase peptide specificity and substrate recruitment.
    Cell Cycle, Vol. 4, No. 1. (Jan 2005), pp. 52-56.
    by Guozhi Zhu, Yin Liu, Stephen Shaw
    posted to human kinase amino-acid activation article-predikin enzyme fragments interaction mapping peptide phosphorylation protein sequence signal specificity substrate transduction by neils on 2007-12-04 03:22:14 as **
  • GPS: a comprehensive www server for phosphorylation sites prediction.
    Nucleic Acids Res, Vol. 33, No. Web Server issue. (Jul 2005), pp. W184-W187.
    by Yu Xue, Fengfeng Zhou, Minjie Zhu, Kashif Ahmed, Guoliang Chen, Xuebiao Yao
    posted to phosphoprotein kinase analysis article-nar article-predikin internet microfilament phosphorylation protein sequence software specificity substrate tissue by neils on 2007-12-04 03:22:14 as **
  • PPSP: prediction of PK-specific phosphorylation site with Bayesian decision theory.
    BMC Bioinformatics, Vol. 7 (2006)
    by Yu Xue, Ao Li, Lirong Wang, Huanqing Feng, Xuebiao Yao
    posted to kinase amino-acid alignment analysis article-nar article-predikin bayes binding data molecular phosphorylation protein sequence sites software theorem by neils on 2007-12-04 03:22:14 as **
  • Calcium/calmodulin-dependent protein kinase II (CaMKII) localization acts in concert with substrate targeting to create spatial restriction for phosphorylation.
    J Biol Chem, Vol. 280, No. 10. (Mar 2005), pp. 9210-9216.
    by Jennifer Tsui, Masaki Inagaki, Howard Schulman
    posted to human article-predikin calcium-calmodulin-dependent cell chain fusion kinase kinetics line membrane microdomains phosphorylation polymerase protein reaction recombinant signal transduction transfection transport type by neils on 2007-12-04 03:22:14 as **
  • The Bioperl toolkit: Perl modules for the life sciences.
    Genome Res, Vol. 12, No. 10. (Oct 2002), pp. 1611-1618.
    by Jason E Stajich, David Block, Kris Boulez, Steven E Brenner, Stephen A Chervitz, Chris Dagdigian, Georg Fuellen, James GR Gilbert, Ian Korf, Hilmar Lapp, Heikki Lehväslaiho, Chad Matsalla, Chris J Mungall, Brian I Osborne, Matthew R Pocock, Peter Schattner, Martin Senger, Lincoln D Stein, Elia Stupka, Mark D Wilkinson, Ewan Birney
    posted to system human animal algorithm genetics article-nar article-predikin biological biology computational computer database design graphics integration internet management online perl sciences software by neils on 2007-12-04 03:22:14 as **
  • ROCR: visualizing classifier performance in R.
    Bioinformatics, Vol. 21, No. 20. (Oct 2005), pp. 3940-3941.
    by Tobias Sing, Oliver Sander, Niko Beerenwinkel, Thomas Lengauer
    posted to statistics article-nar article-predikin automated computer curve data graphics interface interpretation languages pattern programming recognition roc software user-computer validation by neils on 2007-12-04 03:22:14 as **
  • Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.
    J Mol Biol, Vol. 322, No. 4. (Sep 2002), pp. 785-797.
    by James E Sillibourne, Diane M Milne, Mikiko Takahashi, Yoshitaka Ono, David W Meek
    posted to human animal rat cell amino-acid adaptor aethiops anchor article-predikin carrier casein catalysis centrosome cercopithecus cos cytoskeletal data fractions fragments fusion isoenzymes kinase male molecular peptide precipitin protein recombinant sequence signal specificity structure subcellular substrate tertiary tests transducing by neils on 2007-12-04 03:22:14 as **
  • Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.
    Mol Cell Biol, Vol. 23, No. 14. (Jul 2003), pp. 4796-4804.
    by Philippe P Roux, Stephanie A Richards, John Blenis
    posted to human cell amino-acid factors 90-kda article-predikin binding cultured data epidermal extracellular growth homology isoenzymes kinase matrix mitogen-activated mitogens molecular mutation phosphorylation protein ribosomal s6 sequence serine signal sites structure tertiary transduction by neils on 2007-12-04 03:22:14 as **
  • Docking interactions in protein kinase and phosphatase networks.
    Curr Opin Struct Biol, Vol. 16, No. 6. (Dec 2006), pp. 676-685.
    by Attila Reményi, Matthew C Good, Wendell A Lim
    posted to phosphatase complex allosteric article-predikin binding biological conformation design drug kinase map models molecular multiprotein phosphoprotein protein regulation signal signaling sites structure system tertiary transduction by neils on 2007-12-04 03:22:14 as **
  • R: A Language and Environment for Statistical Computing
    (2007)
    by R-Foundation
    posted to article-predikin by neils on 2007-12-04 03:22:14 as **
  • A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.
    J Mol Biol, Vol. 361, No. 2. (Aug 2006), pp. 312-326.
    by Michelle Pirruccello, Holger Sondermann, Jeffrey G Pelton, Patricia Pellicena, André Hoelz, Jonathan Chernoff, David E Wemmer, John Kuriyan
    posted to human kinase amino-acid activation article-predikin binding catalysis catalytic conformation crystallography data dimerization domain enzyme folding homology kinetics models molecular mutation p21-activated phosphopeptides phosphorylation protein protein-serine-threonine sequence sites structure tertiary x-ray by neils on 2007-12-04 03:22:14 as **
  • How do protein kinases recognize their substrates?
    Biochim Biophys Acta, Vol. 1314, No. 3. (Dec 1996), pp. 191-225.
    by LA Pinna, M Ruzzene
    posted to animal kinase amino-acid article-predikin consensus data library molecular peptide phosphorylation protein sequence specificity substrate by neils on 2007-12-04 03:22:14 as **
  • Protein kinase inhibitors: insights into drug design from structure.
    Science, Vol. 303, No. 5665. (Mar 2004), pp. 1800-1805.
    by Martin EM Noble, Jane A Endicott, Louise N Johnson
    posted to inhibitor human adenosine agents antineoplastic article-predikin as binding catalytic clinical conformation design domain drug enzyme kinase models molecular protein relationship signal sites structure structure-activity tertiary topic transduction trials triphosphate by neils on 2007-12-04 03:22:14 as **
  • pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.
    Biol Direct, Vol. 2 (2007)
    by Georg Neuberger, Georg Schneider, Frank Eisenhaber
    posted to article-predikin by neils on 2007-12-04 03:22:14 as **
  • Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling.
    J Immunol, Vol. 175, No. 2. (Jul 2005), pp. 656-664.
    by Maureen A Mcgargill, Leslie L Sharp, Jack D Bui, Stephen M Hedrick, Sébastien Calbo
    posted to subset peptide human antigen animal receptor domain article-predikin c57bl ca2-calmodulin calcium cd3 cell dependent differentiation female fluid homology inbred intracellular isoenzymes kinase knockout line lymphocyte male mice p56lck phosphorylation protein protein-tyrosine-phosphatase signal signaling specific src t-cell t-lymphocyte transduction transgenic tumor tyrosine by neils on 2007-12-04 03:22:14 as **
  • Systematic discovery of in vivo phosphorylation networks.
    Cell, Vol. 129, No. 7. (Jun 2007), pp. 1415-1426.
    by Rune Linding, Lars J Jensen, Gerard J Ostheimer, Marcel ATM van Vugt, Claus Jørgensen, Ioana M Miron, Francesca Diella, Karen Colwill, Lorne Taylor, Kelly Elder, Pavel Metalnikov, Vivian Nguyen, Adrian Pasculescu, Jing Jin, Jin G Park, Leona D Samson, James R Woodgett, Robert B Russell, Peer Bork, Michael B Yaffe, Tony Pawson
    posted to phosphoprotein peptide human enzyme article-predikin binding biology cdc2 cell computational cycle damage dna dna-binding factors glycogen intracellular kinase phosphorylation protein protein-serine-threonine proteomics repair repressor signal signaling sites software suppressor synthase transcription transduction tumor by neils on 2007-12-04 03:22:14 as **
  • Protein disorder prediction: implications for structural proteomics.
    Structure, Vol. 11, No. 11. (Nov 2003), pp. 1453-1459.
    by Rune Linding, Lars J Jensen, Francesca Diella, Peer Bork, Toby J Gibson, Robert B Russell
    posted to network ray ligand domain article-nar article-predikin circular computer conformation crystallography dichroism homology magnetic models neural protein proteome resonance sensitivity specificity spectroscopy src statistics temperature theoretical topic ultraviolet x-ray by neils on 2007-12-04 03:22:13 as **
  • Identification of residues which regulate activity of the STE20-related kinase hMINK.
    Biochem Biophys Res Commun, Vol. 300, No. 3. (Jan 2003), pp. 694-698.
    by Jaeseung Lim, Andrew Lennard, Paul W Sheppard, Stuart Kellie
    posted to human channel kinase amino-acid antibody article-predikin cell cerevisiae cloning data jnk kidney line mitogen-activated molecular mutagenesis organ phosphorylation potassium protein protein-serine-threonine relationship saccharomyces sequence site-directed specificity structure structure-activity tertiary voltage-gated by neils on 2007-12-04 03:22:13 as **
  • SMART 5: domains in the context of genomes and networks.
    Nucleic Acids Res, Vol. 34, No. Database issue. (Jan 2006), pp. D257-D260.
    by Ivica Letunic, Richard R Copley, Birgit Pils, Stefan Pinkert, Jörg Schultz, Peer Bork
    posted to complex database alignment analysis article-nar article-pka-pkg article-predikin biological catalysis catalytic domain genomics interface internet models multiprotein protein sequence structure tertiary user-computer by neils on 2007-12-04 03:22:13 as **
  • The active conformation of the PAK1 kinase domain.
    Structure, Vol. 13, No. 5. (May 2005), pp. 769-778.
    by Ming Lei, Michael A Robinson, Stephen C Harrison
    posted to human kinase adenosine article-predikin binding data diffraction molecular mutation protein protein-serine-threonine sequence sites structure tertiary triphosphate x-ray by neils on 2007-12-04 03:22:13 as **
  • Machine learning in bioinformatics.
    Brief Bioinform, Vol. 7, No. 1. (Mar 2006), pp. 86-112.
    by Pedro Larrañaga, Borja Calvo, Roberto Santana, Concha Bielza, Josu Galdiano, Iñaki Inza, José A Lozano, Rubén Armañanzas, Guzmán Santafé, Aritz Pérez, Victor Robles
    posted to article-predikin by neils on 2007-12-04 03:22:13 as **
  • Structural modes of stabilization of permissive phosphorylation sites in protein kinases: distinct strategies in Ser/Thr and Tyr kinases.
    J Mol Biol, Vol. 339, No. 5. (Jun 2004), pp. 1025-1039.
    by A Krupa, G Preethi, N Srinivasan
    posted to kinase amino-acid activation adenosine alignment article-predikin catalytic data domain enzyme models molecular phosphorylation protein protein-serine-threonine protein-tyrosine sequence signal structure tertiary transduction triphosphate by neils on 2007-12-04 03:22:13 as **
  • Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
    J Mol Biol, Vol. 305, No. 3. (Jan 2001), pp. 567-580.
    by A Krogh, B Larsson, G von Heijne, EL Sonnhammer
    posted to fungi chain signal porin database bacteria article-nar article-predikin computational design genome internet markov membrane of plant protein reproducibility research results secondary sensitivity software solubility sorting specificity structure by neils on 2007-12-04 03:22:13 as **
  • Substrate specificity of protein kinases and computational prediction of substrates.
    Biochim Biophys Acta, Vol. 1754, No. 1-2. (Dec 2005), pp. 200-209.
    by Bostjan Kobe, Thorsten Kampmann, Jade K Forwood, Pawel Listwan, Ross I Brinkworth
    posted to phosphatase peptide kinase article-nar article-predikin binding biology computational models molecular phosphoprotein phosphorylation protein secondary sites specificity structure substrate by neils on 2007-12-04 03:22:13 as **
  • Abscisic acid-activated SNRK2 protein kinases function in the gene-regulation pathway of ABA signal transduction by phosphorylating ABA response element-binding factors.
    Plant J, Vol. 44, No. 6. (Dec 2005), pp. 939-949.
    by Yuhko Kobayashi, Michiharu Murata, Hideyuki Minami, Shuhei Yamamoto, Yasuaki Kagaya, Tokunori Hobo, Akiko Yamamoto, Tsukaho Hattori
    posted to regulator protein kinase amino-acid abscisic activation article-predikin basic-leucine data elements enzyme expression factors gene growth kinetics molecular oryza osmotic phosphorylation plant pressure protein-serine-threonine recombinant regulation response sativa sequence serine signal transcription transduction zipper by neils on 2007-12-04 03:22:13 as **
  • Prediction of phosphorylation sites using SVMs.
    Bioinformatics, Vol. 20, No. 17. (Nov 2004), pp. 3179-3184.
    by Jong H Kim, Juyoung Lee, Bermseok Oh, Kuchan Kimm, Insong Koh
    posted to phosphotransferase algorithm alignment analysis article-predikin artificial binding chemical computer intelligence models molecular phosphorylation protein relationship sequence simulation sites structure-activity by neils on 2007-12-04 03:22:13 as **
  • Protein kinases and protein phosphatases in prokaryotes: a genomic perspective.
    FEMS Microbiol Lett, Vol. 206, No. 1. (Jan 2002), pp. 1-8.
    by Peter J Kennelly
    posted to phosphatase kinase cell article-predikin phosphoprotein phosphorylation prokaryotic protein by neils on 2007-12-04 03:22:13 as **
  • Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry.
    Biochem J, Vol. 370, No. Pt 2. (Mar 2003), pp. 373-389.
    by Peter J Kennelly
    posted to phosphatase radioisotope kinase activation archaea article-predikin enzyme phosphoprotein phosphorus phylogeny protein by neils on 2007-12-04 03:22:13 as **
  • Biochemical characterization of the tobacco 42-kD protein kinase activated by osmotic stress.
    Plant Physiol, Vol. 136, No. 2. (Oct 2004), pp. 3255-3265.
    by Anna Kelner, Izabela Pekala, Szymon Kaczanowski, Grazyna Muszynska, Grahame D Hardie, Grazyna Dobrowolska
    posted to inhibitor amino-acid activation adenosine article-predikin calcium chlorides data enzyme evolution homology kinase magnesium manganese molecular monophosphate osmotic phylogeny pressure protein sequence specificity substrate tobacco water by neils on 2007-12-04 03:22:13 as **
  • A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit.
    PLoS ONE, Vol. 2, No. 5. (2007)
    by Jim Karagiannis, Mohan K Balasubramanian
    posted to article-predikin by neils on 2007-12-04 03:22:13 as **
  • C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats.
    J Biol Chem, Vol. 279, No. 24. (Jun 2004), pp. 24957-24964.
    by Janice C Jones, Hemali P Phatnani, Timothy A Haystead, Justin A Macdonald, Munir S Alam, Arno L Greenleaf
    posted to antibody kinase amino-acid article-predikin data molecular monoclonal phosphorylation polymerase protein repetitive rna saccharomycetales sequence serine specificity substrate by neils on 2007-12-04 03:22:13 as **
  • Kinomics: methods for deciphering the kinome.
    Nat Methods, Vol. 2, No. 1. (Jan 2005), pp. 17-25.
    by Sam A Johnson, Tony Hunter
    posted to human animal kinase genetics mass-spec adenosine article-nar article-predikin biology computational computer-assisted genome image phosphorylation processing protein proteome software structure techniques tertiary triphosphate by neils on 2007-12-04 03:22:13 as **
  • KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites.
    Nucleic Acids Res, Vol. 33, No. Web Server issue. (Jul 2005), pp. W226-W229.
    by Hsien Da Huang, Tzong Y Lee, Shih W Tzeng, Jorng T Horng
    posted to phosphoprotein chain kinase analysis article-nar article-predikin biology computational internet markov phosphorylation protein sequence software by neils on 2007-12-04 03:22:12 as **
  • Amino acid substitution matrices from protein blocks.
    Proc Natl Acad Sci U S A, Vol. 89, No. 22. (Nov 1992), pp. 10915-10919.
    by S Henikoff, JG Henikoff
    posted to animal protein algorithm amino-acid article-predikin caenorhabditis data drosophila elegans homology lod mathematics molecular probability score sequence software by neils on 2007-12-04 03:22:12 as **
  • Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.
    J Biol Chem, Vol. 281, No. 6. (Feb 2006), pp. 3075-3084.
    by Wen Hao, Tomoko Takano, Julie Guillemette, Joan Papillon, Guohui Ren, Andrey V Cybulsky
    posted to cytochrome dog animal rat factors activation aethiops apoptosis article-predikin calcium caspase catalytic cell cercopithecus complementary cos cycle densitometry dimerization dna domain endoplasmic enzyme eukaryotic factor-2 glucose growth heat-shock hepatocyte hsp70 immunoblotting immunoprecipitation initiation injury ionophores jnk kinase line map membrane mitogen-activated nerve p38 phosphorylation protein protein-serine-threonine proto-oncogene reperfusion reticulum structure tertiary tissue tunicamycin by neils on 2007-12-04 03:22:12 as **
  • BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.
    Biochem Biophys Res Commun, Vol. 347, No. 4. (Sep 2006), pp. 867-871.
    by Zekun Guo, Wenwen Tang, Jian Yuan, Xinya Chen, Bo Wan, Xiuting Gu, Kuntian Luo, Yingli Wang, Long Yu
    posted to kinase amino-acid activation alignment amp-dependent article-predikin cyclic data enzyme molecular phosphorylation protein protein-serine-threonine sequence threonine by neils on 2007-12-04 03:22:12 as **
  • Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.
    J Biol Chem, Vol. 279, No. 6. (Feb 2004), pp. 4612-4624.
    by Katrin de Graaf, Paul Hekerman, Oliver Spelten, Andreas Herrmann, Len C Packman, Konrad Büssow, Gerhard M Newen, Walter Becker
    posted to cyclin human animal rat kinase amino-acid arginine article-predikin base cell complementary cos data dna factors fusion male mice molecular nucleus phosphorylation protein protein-serine-threonine protein-tyrosine recombinant rna sequence serine specificity splicing structure substrate tertiary transcription by neils on 2007-12-04 03:22:12 as **
  • Pfam: clans, web tools and services.
    Nucleic Acids Res, Vol. 34, No. Database issue. (Jan 2006), pp. D247-D251.
    by Robert D Finn, Jaina Mistry, Benjamin S Böckler, Sam G Jones, Volker Hollich, Timo Lassmann, Simon Moxon, Mhairi Marshall, Ajay Khanna, Richard Durbin, Sean R Eddy, Erik LL Sonnhammer, Alex Bateman
    posted to chain database alignment article-predikin computer graphics interface internet markov protein sequence software structure tertiary user-computer by neils on 2007-12-04 03:22:12 as **
  • ROC graphs: Notes and practical considerations for data mining researchers
    (July January 2003)
    by Tom Fawcett
    posted to article-predikin by neils on 2007-12-04 03:22:12 as **
  • Profile hidden Markov models.
    Bioinformatics, Vol. 14, No. 9. (1998), pp. 755-763.
    by SR Eddy
    posted to chain alignment article-nar article-predikin hmm library markov peptide sequence software by neils on 2007-12-04 03:22:12 as **
  • The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
    Proc Natl Acad Sci U S A, Vol. 101, No. 32. (Aug 2004), pp. 11886-11890.
    by Anuwat Dinudom, Andrew B Fotia, Robert J Lefkowitz, John A Young, Sharad Kumar, David I Cook
    posted to duct channel animal kinase cell amp-dependent article-predikin beta-adrenergic biochemical cattle chemical cultured cyclic electrophysiology epithelial feedback g-protein-coupled hypertension ligases male mice models phosphorylation protein receptor salivary sodium ubiquitin-protein by neils on 2007-12-04 03:22:12 as **
  • Phospho.ELM: a database of experimentally verified phosphorylation sites in eukaryotic proteins.
    BMC Bioinformatics, Vol. 5 (Jun 2004)
    by Francesca Diella, Scott Cameron, Christine Gemünd, Rune Linding, Allegra Via, Bernhard Kuster, Thomas S Pontén, Nikolaj Blom, Toby J Gibson
    posted to human animal rat database article-predikin binding design mice phosphorylation post-translational processing protein research sites software by neils on 2007-12-04 03:22:12 as **
  • Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.
    Biochem Biophys Res Commun, Vol. 319, No. 1. (Jun 2004), pp. 130-137.
    by Naomi W Court, Ivana Kuo, Oonagh Quigley, Marie A Bogoyevitch
    posted to human animal rat adaptor article-predikin binding cardiac carrier cell glutathione jnk kinase line map mitochondria mitogen-activated mutagenesis mutation myocytes phosphorylation protein serine signal signaling site-directed specificity structure substrate system tertiary transducing transferase by neils on 2007-12-04 03:22:12 as **
  • ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins.
    Nucleic Acids Res, Vol. 34, No. Web Server issue. (Jul 2006), pp. W362-W365.
    by Edouard de Castro, Christian JA Sigrist, Alexandre Gattiker, Virginie Bulliard, Petra, Elisabeth Gasteiger, Amos Bairoch, Nicolas Hulo
    posted to database amino-acid analysis article-predikin homology interface internet protein sequence software structure tertiary user-computer by neils on 2007-12-04 03:22:12 as **
  • A kinase sequence database: sequence alignments and family assignment.
    Bioinformatics, Vol. 18, No. 9. (Sep 2002), pp. 1274-1275.
    by Oleksandr Buzko, Kevan M Shokat
    posted to system kinase alignment analysis article-predikin cluster database homology information internet management protein retrieval sequence storage by neils on 2007-12-04 03:22:12 as **
  • Protein kinases associated with the yeast phosphoproteome.
    BMC Bioinformatics, Vol. 7 (2006)
    by Ross I Brinkworth, Alan L Munn, Bostjan Kobe
    posted to phosphoprotein fungi kinase amino-acid alignment analysis article-predikin cerevisiae data interaction mapping molecular phosphorylation protein proteome saccharomyces sequence specificity