Automatic spike detection based on adaptive template matching for extracellular neural recordings

@article{citeulike:1560289, abstract = {Recordings of extracellular neural activity are used in many clinical applications and scientific studies. In most cases, these signals are analyzed as a point process, and a spike detection algorithm is required to estimate the times at which action potentials occurred. Recordings from high-density microelectrode arrays (MEAs) and low-impedance microelectrodes often have a low signal-to-noise ratio (SNR < 10) and contain action potentials from more than one neuron. We describe a new detection algorithm based on template matching that only requires the user to specify the minimum and maximum firing rates of the neurons. The algorithm iteratively estimates the morphology of the most prominent action potentials. It is able to achieve a sensitivity of >90\% with a false positive rate of <5 Hz in recordings with an estimated SNR = 3, and it performs better than an optimal threshold detector in recordings with an estimated SNR > 2.5.}, author = {Kim, Sunghan and Mcnames, James }, citeulike-article-id = {1560289}, doi = {10.1016/j.jneumeth.2007.05.033}, journal = {Journal of Neuroscience Methods}, keywords = {extracellular-recordings, methods, spike-sorting}, month = {September}, number = {2}, pages = {165--174}, posted-at = {2007-08-14 14:29:37}, priority = {2}, title = {Automatic spike detection based on adaptive template matching for extracellular neural recordings}, url = {http://dx.doi.org/10.1016/j.jneumeth.2007.05.033}, volume = {165}, year = {2007} }

TY - JOUR ID - citeulike:1560289 L3 - citeulike-article-id:1560289 TI - Automatic spike detection based on adaptive template matching for extracellular neural recordings JF - Journal of Neuroscience Methods VL - 165 IS - 2 SP - 165 EP - 174 N2 - Recordings of extracellular neural activity are used in many clinical applications and scientific studies. In most cases, these signals are analyzed as a point process, and a spike detection algorithm is required to estimate the times at which action potentials occurred. Recordings from high-density microelectrode arrays (MEAs) and low-impedance microelectrodes often have a low signal-to-noise ratio (SNR < 10) and contain action potentials from more than one neuron. We describe a new detection algorithm based on template matching that only requires the user to specify the minimum and maximum firing rates of the neurons. The algorithm iteratively estimates the morphology of the most prominent action potentials. It is able to achieve a sensitivity of >90% with a false positive rate of <5 Hz in recordings with an estimated SNR = 3, and it performs better than an optimal threshold detector in recordings with an estimated SNR > 2.5. KW - extracellular-recordings KW - methods KW - spike-sorting AU - Kim, Sunghan AU - Mcnames, James PY - 2007/09/30/ UR - http://dx.doi.org/10.1016/j.jneumeth.2007.05.033 ER -