Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance

@article{citeulike:1604222, abstract = {Edited by Fred H. Gage, The Salk Institute for Biological Sciences, San Diego, CA, and approved July 20, 2007 (received for review February 27, 2007)The hippocampal formation is believed to be critical for the encoding, consolidation, and retrieval of episodic memories. Yet, how these processes are supported by the anatomically diverse hippocampal networks is still unknown. To examine this issue, we tested rats in a hippocampus-dependent delayed spatial alternation task on a modified T maze while simultaneously recording local field potentials from dendritic and somatic layers of the dentate gyrus, CA3, and CA1 regions by using high-density, 96-site silicon probes. Both the power and coherence of gamma oscillations exhibited layer-specific changes during task performance. Peak increases in the gamma power and coherence were found in the CA3CA1 interface on the maze segment approaching the T junction, independent of motor aspects of task performance. These results show that hippocampal networks can be dynamically coupled by gamma oscillations according to specific behavioral demands. Based on these findings, we propose that gamma oscillations may serve as a physiological mechanism by which CA3 output can coordinate CA1 activity to support retrieval of hippocampus-dependent memories. 10.1073/pnas.0701826104}, author = {Montgomery, Sean M. and Buzsaki, Gyorgy }, citeulike-article-id = {1604222}, doi = {10.1073/pnas.0701826104}, journal = {PNAS}, keywords = {binding, ca1, ca3, gamma, hippocampus, oscillations, synchronization}, month = {August}, pages = {0701826104+}, posted-at = {2007-08-29 09:23:48}, priority = {2}, title = {Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance}, url = {http://dx.doi.org/10.1073/pnas.0701826104}, year = {2007} }

TY - JOUR ID - citeulike:1604222 L3 - citeulike-article-id:1604222 TI - Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance JF - PNAS SP - 0701826104 N2 - Edited by Fred H. Gage, The Salk Institute for Biological Sciences, San Diego, CA, and approved July 20, 2007 (received for review February 27, 2007)The hippocampal formation is believed to be critical for the encoding, consolidation, and retrieval of episodic memories. Yet, how these processes are supported by the anatomically diverse hippocampal networks is still unknown. To examine this issue, we tested rats in a hippocampus-dependent delayed spatial alternation task on a modified T maze while simultaneously recording local field potentials from dendritic and somatic layers of the dentate gyrus, CA3, and CA1 regions by using high-density, 96-site silicon probes. Both the power and coherence of gamma oscillations exhibited layer-specific changes during task performance. Peak increases in the gamma power and coherence were found in the CA3CA1 interface on the maze segment approaching the T junction, independent of motor aspects of task performance. These results show that hippocampal networks can be dynamically coupled by gamma oscillations according to specific behavioral demands. Based on these findings, we propose that gamma oscillations may serve as a physiological mechanism by which CA3 output can coordinate CA1 activity to support retrieval of hippocampus-dependent memories. 10.1073/pnas.0701826104 KW - binding KW - ca1 KW - ca3 KW - gamma KW - hippocampus KW - oscillations KW - synchronization AU - Montgomery, Sean AU - Buzsaki, Gyorgy PY - 2007/08/28/ UR - http://dx.doi.org/10.1073/pnas.0701826104 ER -