Recent advances in immunoinformatics: Application of in silico tools to drug development.

by: MC Evans

Curr Opin Drug Discov Devel, Vol. 11, No. 2. (March 2008), pp. 233-241.

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Abstract

Immunoinformatics is an emerging specialization of bioinformatics that focuses upon the structure, function and interactions of the molecules involved in immunity. Two major cell types, T-cells and B-cells, play significant roles in allergy, inflammation, infection and protective immunity. This review examines recently developed in silico tools and databases that can be used to identify, characterize or predict antigen epitopes recognized by T- and B-cells including the latest generation of B-cell epitope prediction tools that employ peptide-binding information derived from peptide phage display experiments. The application of these tools to facilitate drug development efforts is also discussed.

@article{citeulike:2410288, abstract = {Immunoinformatics is an emerging specialization of bioinformatics that focuses upon the structure, function and interactions of the molecules involved in immunity. Two major cell types, T-cells and B-cells, play significant roles in allergy, inflammation, infection and protective immunity. This review examines recently developed in silico tools and databases that can be used to identify, characterize or predict antigen epitopes recognized by T- and B-cells including the latest generation of B-cell epitope prediction tools that employ peptide-binding information derived from peptide phage display experiments. The application of these tools to facilitate drug development efforts is also discussed.}, address = {Research Informatics, Preclinical Research and Development, XOMA (US) LLC, 2910 Seventh Street, Berkeley, CA 94710, USA. evans@xoma.com.}, author = {Evans, M. C. }, citeulike-article-id = {2410288}, issn = {1367-6733}, journal = {Curr Opin Drug Discov Devel}, keywords = {immunoinformatics}, month = {March}, number = {2}, pages = {233--241}, posted-at = {2008-04-01 10:38:04}, priority = {2}, title = {Recent advances in immunoinformatics: Application of in silico tools to drug development.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18283611}, volume = {11}, year = {2008} }

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TY - JOUR ID - citeulike:2410288 L3 - citeulike-article-id:2410288 TI - Recent advances in immunoinformatics: Application of in silico tools to drug development. JF - Curr Opin Drug Discov Devel VL - 11 IS - 2 SP - 233 EP - 241 AD - Research Informatics, Preclinical Research and Development, XOMA (US) LLC, 2910 Seventh Street, Berkeley, CA 94710, USA. evans@xoma.com. SN - 1367-6733 N2 - Immunoinformatics is an emerging specialization of bioinformatics that focuses upon the structure, function and interactions of the molecules involved in immunity. Two major cell types, T-cells and B-cells, play significant roles in allergy, inflammation, infection and protective immunity. This review examines recently developed in silico tools and databases that can be used to identify, characterize or predict antigen epitopes recognized by T- and B-cells including the latest generation of B-cell epitope prediction tools that employ peptide-binding information derived from peptide phage display experiments. The application of these tools to facilitate drug development efforts is also discussed. KW - immunoinformatics AU - Evans, MC PY - 2008/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/18283611 ER -

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