Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat.

@article{citeulike:480582, abstract = {The role of the prelimbic cortex (PL) in rats was investigated with excitotoxic lesions. PL lesions altered the alternation scores in spontaneous and reinforced spatial delayed-alternation tasks. PL lesions induced a delay in conditioning under a temporal go/no-go alternation schedule but not under a continuous food-reinforcement schedule in a runway. PL lesions had no effect on the acquisition of a standard radial-arm-maze task nor on a fixed-goal location task but disrupted the acquisition of a variable-goal location task in a radial-arm maze. The present results indicate that PL lesions replicated most of the behavioral deficits obtained with larger prefrontal lesions. PL lesions disrupted the acquisition of delayed-variable response tasks while leaving unaffected fixed-response tasks. These results are discussed in relation with a working-memory, a response-selection, and an attentional hypothesis.}, address = {Laboratoire de Neurobiologie de I'Apprentissage et de la M\'{e}moire, Universit\'{e} Paris-Sud, Orsay, France.}, author = {Delatour, B. and Gisquet-Verrier, P. }, citeulike-article-id = {480582}, issn = {0735-7044}, journal = {Behav Neurosci}, keywords = {nrsa}, month = {December}, number = {6}, pages = {1282--1298}, posted-at = {2006-01-25 16:17:47}, priority = {2}, title = {Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8986332}, volume = {110}, year = {1996} }

TY - JOUR ID - citeulike:480582 L3 - citeulike-article-id:480582 TI - Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat. JF - Behav Neurosci VL - 110 IS - 6 SP - 1282 EP - 1298 AD - Laboratoire de Neurobiologie de I'Apprentissage et de la Mémoire, Université Paris-Sud, Orsay, France. SN - 0735-7044 N2 - The role of the prelimbic cortex (PL) in rats was investigated with excitotoxic lesions. PL lesions altered the alternation scores in spontaneous and reinforced spatial delayed-alternation tasks. PL lesions induced a delay in conditioning under a temporal go/no-go alternation schedule but not under a continuous food-reinforcement schedule in a runway. PL lesions had no effect on the acquisition of a standard radial-arm-maze task nor on a fixed-goal location task but disrupted the acquisition of a variable-goal location task in a radial-arm maze. The present results indicate that PL lesions replicated most of the behavioral deficits obtained with larger prefrontal lesions. PL lesions disrupted the acquisition of delayed-variable response tasks while leaving unaffected fixed-response tasks. These results are discussed in relation with a working-memory, a response-selection, and an attentional hypothesis. KW - nrsa AU - Delatour, B AU - Gisquet-Verrier, P PY - 1996/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/8986332 ER -