Learning Induces Long-Term Potentiation in the Hippocampus

by: Jonathan R Whitlock, Arnold J Heynen, Marshall G Shuler, Mark F Bear

Science, Vol. 313, No. 5790. (25 August 2006), pp. 1093-1097.

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Abstract

Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1. 10.1126/science.1128134

@article{citeulike:816402, abstract = {Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1. 10.1126/science.1128134}, author = {Whitlock, Jonathan R. and Heynen, Arnold J. and Shuler, Marshall G. and Bear, Mark F. }, citeulike-article-id = {816402}, doi = {http://dx.doi.org/10.1126/science.1128134}, journal = {Science}, keywords = {ltm}, month = {August}, number = {5790}, pages = {1093--1097}, posted-at = {2006-08-29 01:50:30}, priority = {2}, title = {Learning Induces Long-Term Potentiation in the Hippocampus}, url = {http://dx.doi.org/10.1126/science.1128134}, volume = {313}, year = {2006} }

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TY - JOUR ID - citeulike:816402 L3 - citeulike-article-id:816402 TI - Learning Induces Long-Term Potentiation in the Hippocampus JF - Science VL - 313 IS - 5790 SP - 1093 EP - 1097 N2 - Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1. 10.1126/science.1128134 KW - ltm AU - Whitlock, Jonathan AU - Heynen, Arnold AU - Shuler, Marshall AU - Bear, Mark PY - 2006/08/25/ UR - http://dx.doi.org/10.1126/science.1128134 ER -

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