Dopamine: the salient issue.

by: MA Ungless

Trends Neurosci, Vol. 27, No. 12. (December 2004), pp. 702-706.

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Abstract

There is general agreement that midbrain dopamine neurons play key roles in reward processing. What is more controversial is the role they play in processing salient stimuli that are not rewarding. This controversy has arisen for three main reasons. First, salient sensory stimuli such as tones and lights, which are assumed not to be rewarding, increase dopamine neuron activity. Second, aversive stimuli increase firing in a minority of putative dopamine neurons. Third, dopamine release is increased following aversive stimuli. Consequently, it has been suggested that these midbrain dopamine neurons are activated by all salient stimuli, rather than specifically by rewards. However, reconsideration of these issues, in light of new findings, suggests this controversy can be resolved in favour of reward theories.

@article{citeulike:126754, abstract = {There is general agreement that midbrain dopamine neurons play key roles in reward processing. What is more controversial is the role they play in processing salient stimuli that are not rewarding. This controversy has arisen for three main reasons. First, salient sensory stimuli such as tones and lights, which are assumed not to be rewarding, increase dopamine neuron activity. Second, aversive stimuli increase firing in a minority of putative dopamine neurons. Third, dopamine release is increased following aversive stimuli. Consequently, it has been suggested that these midbrain dopamine neurons are activated by all salient stimuli, rather than specifically by rewards. However, reconsideration of these issues, in light of new findings, suggests this controversy can be resolved in favour of reward theories.}, address = {MRC Anatomical Neuropharmacology Unit, Department of Pharmacology and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. mark.ungless@zoo.ox.ac.uk}, author = {Ungless, M. A. }, citeulike-article-id = {126754}, doi = {10.1016/j.tins.2004.10.001}, issn = {0166-2236}, journal = {Trends Neurosci}, keywords = {caffeine, decision-making, dopamine, learning, mice, reinforcement, reward}, month = {December}, number = {12}, pages = {702--706}, posted-at = {2005-03-14 18:35:30}, priority = {3}, title = {Dopamine: the salient issue.}, url = {http://dx.doi.org/10.1016/j.tins.2004.10.001}, volume = {27}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:126754 L3 - citeulike-article-id:126754 TI - Dopamine: the salient issue. JF - Trends Neurosci VL - 27 IS - 12 SP - 702 EP - 706 AD - MRC Anatomical Neuropharmacology Unit, Department of Pharmacology and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. mark.ungless@zoo.ox.ac.uk SN - 0166-2236 N2 - There is general agreement that midbrain dopamine neurons play key roles in reward processing. What is more controversial is the role they play in processing salient stimuli that are not rewarding. This controversy has arisen for three main reasons. First, salient sensory stimuli such as tones and lights, which are assumed not to be rewarding, increase dopamine neuron activity. Second, aversive stimuli increase firing in a minority of putative dopamine neurons. Third, dopamine release is increased following aversive stimuli. Consequently, it has been suggested that these midbrain dopamine neurons are activated by all salient stimuli, rather than specifically by rewards. However, reconsideration of these issues, in light of new findings, suggests this controversy can be resolved in favour of reward theories. KW - caffeine KW - decision-making KW - dopamine KW - learning KW - mice KW - reinforcement KW - reward AU - Ungless, MA PY - 2004/12// UR - http://dx.doi.org/10.1016/j.tins.2004.10.001 ER -

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