Cellular inhibitors of long interspersed element 1 and Alu retrotransposition

by: Hal P Bogerd, Heather L Wiegand, Amy E Hulme, Jose L Garcia-Perez, Sue K O'Shea, John V Moran, Bryan R Cullen

PNAS, Vol. 103, No. 23. (6 June 2006), pp. 8780-8785.

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Abstract

Long interspersed element (LINE) 1 retrotransposons are major genomic parasites that represent approx17% of the human genome. The LINE-1 ORF2 protein is also responsible for the mobility of Alu elements, which constitute a further approx11% of genomic DNA. Representative members of each element class remain mobile, and deleterious retrotransposition events can induce spontaneous genetic diseases. Here, we demonstrate that APOBEC3A and APOBEC3B, two members of the APOBEC3 family of human innate antiretroviral resistance factors, can enter the nucleus, where LINE-1 and Alu reverse transcription occurs, and specifically inhibit both LINE-1 and Alu retrotransposition. These data suggest that the APOBEC3 protein family may have evolved, at least in part, to defend the integrity of the human genome against endogenous retrotransposons. 10.1073/pnas.0603313103

@article{citeulike:891299, abstract = {Long interspersed element (LINE) 1 retrotransposons are major genomic parasites that represent {approx}17\% of the human genome. The LINE-1 ORF2 protein is also responsible for the mobility of Alu elements, which constitute a further {approx}11\% of genomic DNA. Representative members of each element class remain mobile, and deleterious retrotransposition events can induce spontaneous genetic diseases. Here, we demonstrate that APOBEC3A and APOBEC3B, two members of the APOBEC3 family of human innate antiretroviral resistance factors, can enter the nucleus, where LINE-1 and Alu reverse transcription occurs, and specifically inhibit both LINE-1 and Alu retrotransposition. These data suggest that the APOBEC3 protein family may have evolved, at least in part, to defend the integrity of the human genome against endogenous retrotransposons. 10.1073/pnas.0603313103}, author = {Bogerd, Hal P. and Wiegand, Heather L. and Hulme, Amy E. and Garcia-Perez, Jose L. and O'Shea, Sue K. and Moran, John V. and Cullen, Bryan R. }, citeulike-article-id = {891299}, doi = {10.1073/pnas.0603313103}, journal = {PNAS}, keywords = {alu, apobec, inhibition, l1}, month = {June}, number = {23}, pages = {8780--8785}, posted-at = {2008-03-10 14:51:16}, priority = {0}, title = {Cellular inhibitors of long interspersed element 1 and Alu retrotransposition}, url = {http://dx.doi.org/10.1073/pnas.0603313103}, volume = {103}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:891299 L3 - citeulike-article-id:891299 TI - Cellular inhibitors of long interspersed element 1 and Alu retrotransposition JF - PNAS VL - 103 IS - 23 SP - 8780 EP - 8785 N2 - Long interspersed element (LINE) 1 retrotransposons are major genomic parasites that represent {approx}17% of the human genome. The LINE-1 ORF2 protein is also responsible for the mobility of Alu elements, which constitute a further {approx}11% of genomic DNA. Representative members of each element class remain mobile, and deleterious retrotransposition events can induce spontaneous genetic diseases. Here, we demonstrate that APOBEC3A and APOBEC3B, two members of the APOBEC3 family of human innate antiretroviral resistance factors, can enter the nucleus, where LINE-1 and Alu reverse transcription occurs, and specifically inhibit both LINE-1 and Alu retrotransposition. These data suggest that the APOBEC3 protein family may have evolved, at least in part, to defend the integrity of the human genome against endogenous retrotransposons. 10.1073/pnas.0603313103 KW - alu KW - apobec KW - inhibition KW - l1 AU - Bogerd, Hal AU - Wiegand, Heather AU - Hulme, Amy AU - Garcia-Perez, Jose AU - O'Shea, Sue AU - Moran, John AU - Cullen, Bryan PY - 2006/06/06/ UR - http://dx.doi.org/10.1073/pnas.0603313103 ER -

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