The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction

@article{citeulike:1747179, abstract = {The uncoupling of mitochondrial energy transduction by excess Ca2+ may be a factor in the pathogenesis of tissue injury brought about by energy deprivation, for example, in ischaemia. In isolated mitochondria the lesion appears as a large, 20A, pore in the inner membrane. The pore is blocked potently by the immunosuppressant cyclosporin A. Cyclosporin A also markedly retards collapse of the mitochondrial inner membrane potential in energy-deprived (respiration-inhibited) cardiomyocytes as judged by changes in rhodamine 123 fluorescence, and prolongs cell viability. A potential mitochondrial target for cyclosporin A is the matrix protein cyclophilin. Purified cyclophilin activates the respiratory chain of submitochondrial particles. This might reflect not only a physiological function of this protein, but also a component involved in the generation of the 20Apore under pathological conditions.}, author = {Crompton, M. and Mcguinness, O. and Nazareth, W. }, citeulike-article-id = {1747179}, doi = {http://dx.doi.org/10.1016/0005-2728(92)90228-T}, journal = {Biochimica et Biophysica Acta (BBA) - Bioenergetics}, keywords = {metabolism, mitochondria, permeability, transition}, month = {July}, number = {2}, pages = {214--217}, posted-at = {2007-10-09 22:13:35}, priority = {2}, title = {The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction}, url = {http://dx.doi.org/10.1016/0005-2728(92)90228-T}, volume = {1101}, year = {1992} }

TY - JOUR ID - citeulike:1747179 L3 - citeulike-article-id:1747179 TI - The involvement of cyclosporin A binding proteins in regulating and uncoupling mitochondrial energy transduction JF - Biochimica et Biophysica Acta (BBA) - Bioenergetics VL - 1101 IS - 2 SP - 214 EP - 217 N2 - The uncoupling of mitochondrial energy transduction by excess Ca2+ may be a factor in the pathogenesis of tissue injury brought about by energy deprivation, for example, in ischaemia. In isolated mitochondria the lesion appears as a large, 20A, pore in the inner membrane. The pore is blocked potently by the immunosuppressant cyclosporin A. Cyclosporin A also markedly retards collapse of the mitochondrial inner membrane potential in energy-deprived (respiration-inhibited) cardiomyocytes as judged by changes in rhodamine 123 fluorescence, and prolongs cell viability. A potential mitochondrial target for cyclosporin A is the matrix protein cyclophilin. Purified cyclophilin activates the respiratory chain of submitochondrial particles. This might reflect not only a physiological function of this protein, but also a component involved in the generation of the 20Apore under pathological conditions. KW - metabolism KW - mitochondria KW - permeability KW - transition AU - Crompton, M AU - Mcguinness, O AU - Nazareth, W PY - 1992/07/17/ UR - http://dx.doi.org/10.1016/0005-2728(92)90228-T ER -