Transcription-independent pro-apoptotic functions of p53.

@article{citeulike:2838084, abstract = {Induction of apoptosis is one of the central activities by which p53 exerts its tumor-suppressing function. Aside from its primary function as a transcription factor, it can promote apoptosis independent of transcription. Recent studies have started to define the mechanisms of non-transcriptional pro-apoptotic p53 activities operating within the intrinsic mitochondria-mediated pathway of apoptosis. So far, two different mechanisms have been described, each of which was assigned to a specific localization of the p53 protein, either in the cytosol or directly at the mitochondria. Although mechanistically different, both transcription-independent modes of apoptosis induction converge, as they both initiate permeabilization of the outer mitochondrial membrane via activation of the pro-apoptotic Bcl-2 family members Bax or Bak.}, address = {Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA.}, author = {Moll, U. M. and Wolff, S. and Speidel, D. and Deppert, W. }, citeulike-article-id = {2838084}, doi = {http://dx.doi.org/10.1016/j.ceb.2005.09.007}, issn = {0955-0674}, journal = {Current opinion in cell biology}, keywords = {activation, apoptosis, p53}, month = {December}, number = {6}, pages = {631--636}, posted-at = {2008-05-27 20:03:28}, priority = {2}, title = {Transcription-independent pro-apoptotic functions of p53.}, url = {http://dx.doi.org/10.1016/j.ceb.2005.09.007}, volume = {17}, year = {2005} }

TY - JOUR ID - citeulike:2838084 L3 - citeulike-article-id:2838084 TI - Transcription-independent pro-apoptotic functions of p53. JF - Current opinion in cell biology VL - 17 IS - 6 SP - 631 EP - 636 AD - Department of Pathology, Stony Brook University, Stony Brook, New York 11794, USA. SN - 0955-0674 N2 - Induction of apoptosis is one of the central activities by which p53 exerts its tumor-suppressing function. Aside from its primary function as a transcription factor, it can promote apoptosis independent of transcription. Recent studies have started to define the mechanisms of non-transcriptional pro-apoptotic p53 activities operating within the intrinsic mitochondria-mediated pathway of apoptosis. So far, two different mechanisms have been described, each of which was assigned to a specific localization of the p53 protein, either in the cytosol or directly at the mitochondria. Although mechanistically different, both transcription-independent modes of apoptosis induction converge, as they both initiate permeabilization of the outer mitochondrial membrane via activation of the pro-apoptotic Bcl-2 family members Bax or Bak. KW - activation KW - apoptosis KW - p53 AU - Moll, UM AU - Wolff, S AU - Speidel, D AU - Deppert, W PY - 2005/12// UR - http://dx.doi.org/10.1016/j.ceb.2005.09.007 ER -