Approximative kinetic formats used in metabolic network modeling

@article{citeulike:1693866, abstract = {An overview is presented of the different approximative enzyme kinetic formats that have been proposed for use in metabolic modeling studies. It is considered that the following four general properties are relevant for approximative kinetics: the rate must be proportional to enzyme level; at high metabolite concentrations, there is downward concave behavior of rate versus concentration; the number of kinetic parameters should be as small as possible; analytical solutions of steady-state network balances are desirable. Six different approximative kinetic formats are evaluated (linear, logarithmic-linear, power law GMA, power law S-systems, thermokinetic, linear-logarithmic) and it is concluded that only the recently proposed linear-logarithmic approach combines all desired properties and therefore seems a most appropriate approximate kinetic format. {\copyright} 2005 Wiley Periodicals, Inc.}, address = {Department of Biotechnology, Kluyver Laboratory for Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BL, Delft, The Netherlands; telephone: 31-15-2782341; fax: 31-15-2782355}, author = {Heijnen, Joseph J. }, citeulike-article-id = {1693866}, doi = {10.1002/bit.20558}, journal = {Biotechnology and Bioengineering}, keywords = {kinetics, modelling, review}, number = {5}, pages = {534--545}, posted-at = {2008-06-26 13:56:14}, priority = {3}, title = {Approximative kinetic formats used in metabolic network modeling}, url = {http://dx.doi.org/10.1002/bit.20558}, volume = {91}, year = {2005} }

TY - JOUR ID - citeulike:1693866 L3 - citeulike-article-id:1693866 TI - Approximative kinetic formats used in metabolic network modeling JF - Biotechnology and Bioengineering VL - 91 IS - 5 SP - 534 EP - 545 AD - Department of Biotechnology, Kluyver Laboratory for Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BL, Delft, The Netherlands; telephone: 31-15-2782341; fax: 31-15-2782355 N2 - An overview is presented of the different approximative enzyme kinetic formats that have been proposed for use in metabolic modeling studies. It is considered that the following four general properties are relevant for approximative kinetics: the rate must be proportional to enzyme level; at high metabolite concentrations, there is downward concave behavior of rate versus concentration; the number of kinetic parameters should be as small as possible; analytical solutions of steady-state network balances are desirable. Six different approximative kinetic formats are evaluated (linear, logarithmic-linear, power law GMA, power law S-systems, thermokinetic, linear-logarithmic) and it is concluded that only the recently proposed linear-logarithmic approach combines all desired properties and therefore seems a most appropriate approximate kinetic format. © 2005 Wiley Periodicals, Inc. KW - kinetics KW - modelling KW - review AU - Heijnen, Joseph PY - 2005/// UR - http://dx.doi.org/10.1002/bit.20558 ER -