New roles for the LKB1-->AMPK pathway

by: Grahame G Hardie

Current Opinion in Cell Biology, Vol. 17, No. 2. (April 2005), pp. 167-173.

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Abstract

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy that is conserved throughout eukaryotes. It is activated by rising AMP, signifying falling energy status caused by starvation for a carbon source or other stress. Binding of AMP to the regulatory [gamma] subunit triggers phosphorylation of the catalytic [alpha] subunit by the upstream kinase LKB1, and the activated kinase switches on ATP-generating catabolic pathways while switching off ATP-requiring processes. AMPK inhibits the TOR (target of rapamycin) pathway by phosphorylating TSC2, thus inhibiting cell growth during times of stress. AMPK is also a target for adipokines that regulate energy balance at the whole-body level.

@article{citeulike:138629, abstract = {The AMP-activated protein kinase (AMPK) is a sensor of cellular energy that is conserved throughout eukaryotes. It is activated by rising AMP, signifying falling energy status caused by starvation for a carbon source or other stress. Binding of AMP to the regulatory [gamma] subunit triggers phosphorylation of the catalytic [alpha] subunit by the upstream kinase LKB1, and the activated kinase switches on ATP-generating catabolic pathways while switching off ATP-requiring processes. AMPK inhibits the TOR (target of rapamycin) pathway by phosphorylating TSC2, thus inhibiting cell growth during times of stress. AMPK is also a target for adipokines that regulate energy balance at the whole-body level.}, author = {Hardie, Grahame G. }, citeulike-article-id = {138629}, doi = {10.1016/j.ceb.2005.01.006}, journal = {Current Opinion in Cell Biology}, keywords = {adipokines, ampk, mtor}, month = {April}, number = {2}, pages = {167--173}, posted-at = {2005-03-24 08:38:00}, priority = {2}, title = {New roles for the LKB1-->AMPK pathway}, url = {http://dx.doi.org/10.1016/j.ceb.2005.01.006}, volume = {17}, year = {2005} }

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TY - JOUR ID - citeulike:138629 L3 - citeulike-article-id:138629 TI - New roles for the LKB1-->AMPK pathway JF - Current Opinion in Cell Biology VL - 17 IS - 2 SP - 167 EP - 173 N2 - The AMP-activated protein kinase (AMPK) is a sensor of cellular energy that is conserved throughout eukaryotes. It is activated by rising AMP, signifying falling energy status caused by starvation for a carbon source or other stress. Binding of AMP to the regulatory [gamma] subunit triggers phosphorylation of the catalytic [alpha] subunit by the upstream kinase LKB1, and the activated kinase switches on ATP-generating catabolic pathways while switching off ATP-requiring processes. AMPK inhibits the TOR (target of rapamycin) pathway by phosphorylating TSC2, thus inhibiting cell growth during times of stress. AMPK is also a target for adipokines that regulate energy balance at the whole-body level. KW - adipokines KW - ampk KW - mtor AU - Hardie, Grahame PY - 2005/04// UR - http://dx.doi.org/10.1016/j.ceb.2005.01.006 ER -

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