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Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.

by: D Broek, R Bartlett, K Crawford, P Nurse
Nature, Vol. 349, No. 6308. (31 January 1991), pp. 388-393.


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Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.


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