Chloroplastic Protein NRIP1 Mediates Innate Immune Receptor Recognition of a Viral Effector

@article{citeulike:2387788, abstract = {Summary Plant innate immunity relies on the recognition of pathogen effector molecules by nucleotide-binding-leucine-rich repeat (NB-LRR) immune receptor families. Previously we have shown the N immune receptor, a member of TIR-NB-LRR family, indirectly recognizes the 50 kDa helicase (p50) domain of Tobacco mosaic virus (TMV) through its TIR domain. We have identified an N receptor-interacting protein, NRIP1, that directly interacts with both N's TIR domain and p50. NRIP1 is a functional rhodanese sulfurtransferase and is required for N to provide complete resistance to TMV. Interestingly, NRIP1 that normally localizes to the chloroplasts is recruited to the cytoplasm and nucleus by the p50 effector. As a consequence, NRIP1 interacts with N only in the presence of the p50 effector. Our findings show that a chloroplastic protein is intimately involved in pathogen recognition. We propose that N's activation requires a prerecognition complex containing the p50 effector and NRIP1.}, author = {Caplan, Jeffrey L. and Mamillapalli, Padmavathi and Burch-Smith, Tessa M. and Czymmek, Kirk and Dinesh-Kumar, S. P. }, citeulike-article-id = {2387788}, doi = {10.1016/j.cell.2007.12.031}, journal = {Cell}, keywords = {n, nrip, r}, month = {February}, number = {3}, pages = {449--462}, posted-at = {2008-02-16 02:32:37}, priority = {2}, title = {Chloroplastic Protein NRIP1 Mediates Innate Immune Receptor Recognition of a Viral Effector}, url = {http://dx.doi.org/10.1016/j.cell.2007.12.031}, volume = {132}, year = {2008} }

TY - JOUR ID - citeulike:2387788 L3 - citeulike-article-id:2387788 TI - Chloroplastic Protein NRIP1 Mediates Innate Immune Receptor Recognition of a Viral Effector JF - Cell VL - 132 IS - 3 SP - 449 EP - 462 N2 - Summary Plant innate immunity relies on the recognition of pathogen effector molecules by nucleotide-binding-leucine-rich repeat (NB-LRR) immune receptor families. Previously we have shown the N immune receptor, a member of TIR-NB-LRR family, indirectly recognizes the 50 kDa helicase (p50) domain of Tobacco mosaic virus (TMV) through its TIR domain. We have identified an N receptor-interacting protein, NRIP1, that directly interacts with both N's TIR domain and p50. NRIP1 is a functional rhodanese sulfurtransferase and is required for N to provide complete resistance to TMV. Interestingly, NRIP1 that normally localizes to the chloroplasts is recruited to the cytoplasm and nucleus by the p50 effector. As a consequence, NRIP1 interacts with N only in the presence of the p50 effector. Our findings show that a chloroplastic protein is intimately involved in pathogen recognition. We propose that N's activation requires a prerecognition complex containing the p50 effector and NRIP1. KW - n KW - nrip KW - r AU - Caplan, Jeffrey AU - Mamillapalli, Padmavathi AU - Burch-Smith, Tessa AU - Czymmek, Kirk AU - Dinesh-Kumar, SP PY - 2008/02/08/ UR - http://dx.doi.org/10.1016/j.cell.2007.12.031 ER -