Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking.

@article{citeulike:1926773, abstract = {BACKGROUND: Norepinephrine is implicated in cocaine's behavioral effects. In this study, we tested the effect of prazosin, an alpha1-adrenergic receptor antagonist, on cocaine-induced reinstatement of drug-seeking behavior. METHODS: Rats were trained to self-administer cocaine intravenously under a fixed-ratio 3 schedule of reinforcement. After behavior was established, cocaine was replaced with saline and behavior extinguished. The ability of cocaine (0, 5-20 mg/kg) alone or combined with prazosin (.3 mg/kg) to reinstate lever press responding was tested. The effects of prazosin on lever press responding for food was examined in another set of rats. RESULTS: Cocaine induced a dose-dependent reinstatement of drug-seeking behavior that was significantly attenuated by prazosin. This dose of prazosin did not alter lever press response rates for food. CONCLUSIONS: The attenuation in drug-induced reinstatement is likely not due to prazosin-induced suppression of activity. These results suggest alpha1-adrenergic mechanisms contribute to reinstatement in rats and perhaps, to relapse in addicts.}, address = {Division of Substance Abuse, Yale University School of Medicine, West Haven, Connecticut 06516, USA.}, author = {Zhang, X. Y. and Kosten, T. A. }, citeulike-article-id = {1926773}, doi = {http://dx.doi.org/10.1016/j.biopsych.2005.02.003}, issn = {0006-3223}, journal = {Biol Psychiatry}, month = {May}, number = {10}, pages = {1202--1204}, posted-at = {2007-11-16 15:38:00}, priority = {2}, title = {Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking.}, url = {http://dx.doi.org/10.1016/j.biopsych.2005.02.003}, volume = {57}, year = {2005} }

TY - JOUR ID - citeulike:1926773 L3 - citeulike-article-id:1926773 TI - Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. JF - Biol Psychiatry VL - 57 IS - 10 SP - 1202 EP - 1204 AD - Division of Substance Abuse, Yale University School of Medicine, West Haven, Connecticut 06516, USA. SN - 0006-3223 N2 - BACKGROUND: Norepinephrine is implicated in cocaine's behavioral effects. In this study, we tested the effect of prazosin, an alpha1-adrenergic receptor antagonist, on cocaine-induced reinstatement of drug-seeking behavior. METHODS: Rats were trained to self-administer cocaine intravenously under a fixed-ratio 3 schedule of reinforcement. After behavior was established, cocaine was replaced with saline and behavior extinguished. The ability of cocaine (0, 5-20 mg/kg) alone or combined with prazosin (.3 mg/kg) to reinstate lever press responding was tested. The effects of prazosin on lever press responding for food was examined in another set of rats. RESULTS: Cocaine induced a dose-dependent reinstatement of drug-seeking behavior that was significantly attenuated by prazosin. This dose of prazosin did not alter lever press response rates for food. CONCLUSIONS: The attenuation in drug-induced reinstatement is likely not due to prazosin-induced suppression of activity. These results suggest alpha1-adrenergic mechanisms contribute to reinstatement in rats and perhaps, to relapse in addicts. AU - Zhang, XY AU - Kosten, TA PY - 2005/05/15/ UR - http://dx.doi.org/10.1016/j.biopsych.2005.02.003 ER -