Rheostat regulation of integrin-mediated leukocyte adhesion.

@article{citeulike:2970128, abstract = {The homing of activated T lymphocytes to the gut in inflammatory bowel diseases is dependent on their coordinated, integrin-mediated adhesion and de-adhesion to substrates and blood vessel walls. In this issue of the JCI, Park and colleagues reveal a key modulatory role of a binding site within beta integrins, known as the ADMIDAS domain, in controlling integrin de-adhesion in mice (see the related article beginning on page 2526). These observations add to our growing understanding of how integrin adhesiveness is regulated and raise the notion of the existence of a biological rheostat for lymphocyte homing. Disturbed migratory rheostat tone could account for variations in interindividual immune responses observed in patients with inflammatory bowel disease or other lymphocyte-mediated inflammatory disorders. These findings will inform future strategies to design small molecules for the treatment of a spectrum of chronic inflammatory conditions.}, address = {Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, and Denver Health Medical Center, Denver, Colorado 80204, USA. idouglas@dhha.org}, author = {Douglas, I. S. and Dassopoulos, T. }, citeulike-article-id = {2970128}, doi = {10.1172/JCI33376}, issn = {0021-9738}, journal = {The Journal of clinical investigation}, keywords = {a4b7, colitis, review}, month = {September}, number = {9}, pages = {2391--2395}, posted-at = {2008-07-07 14:41:24}, priority = {2}, title = {Rheostat regulation of integrin-mediated leukocyte adhesion.}, url = {http://dx.doi.org/10.1172/JCI33376}, volume = {117}, year = {2007} }

TY - JOUR ID - citeulike:2970128 L3 - citeulike-article-id:2970128 TI - Rheostat regulation of integrin-mediated leukocyte adhesion. JF - The Journal of clinical investigation VL - 117 IS - 9 SP - 2391 EP - 2395 AD - Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, and Denver Health Medical Center, Denver, Colorado 80204, USA. idouglas@dhha.org SN - 0021-9738 N2 - The homing of activated T lymphocytes to the gut in inflammatory bowel diseases is dependent on their coordinated, integrin-mediated adhesion and de-adhesion to substrates and blood vessel walls. In this issue of the JCI, Park and colleagues reveal a key modulatory role of a binding site within beta integrins, known as the ADMIDAS domain, in controlling integrin de-adhesion in mice (see the related article beginning on page 2526). These observations add to our growing understanding of how integrin adhesiveness is regulated and raise the notion of the existence of a biological rheostat for lymphocyte homing. Disturbed migratory rheostat tone could account for variations in interindividual immune responses observed in patients with inflammatory bowel disease or other lymphocyte-mediated inflammatory disorders. These findings will inform future strategies to design small molecules for the treatment of a spectrum of chronic inflammatory conditions. KW - a4b7 KW - colitis KW - review AU - Douglas, IS AU - Dassopoulos, T PY - 2007/09// UR - http://dx.doi.org/10.1172/JCI33376 ER -