Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks.

@article{citeulike:406429, abstract = {Temporal precision in spike timing is important in cortical function, interactions, and plasticity. We found that, during periods of recurrent network activity (UP states), cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials showing much higher power at all frequencies above approximately 10 Hz and more synchrony between nearby neurons. Fast-spiking inhibitory interneurons discharged strongly in relation to higher-frequency oscillations in the field potential in vivo and possess membrane, synaptic, and action potential properties that are advantageous for transmission of higher-frequency activity. Intracellular injection of synaptic conductances having the characteristics of the recorded EPSPs and IPSPs reveal that IPSPs are important in controlling the timing and probability of action potential generation in pyramidal cells. Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex.}, address = {Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA.}, author = {Hasenstaub, A. and Shu, Y. and Haider, B. and Kraushaar, U. and Duque, A. and McCormick, D. A. }, citeulike-article-id = {406429}, doi = {10.1016/j.neuron.2005.06.016}, issn = {0896-6273}, journal = {Neuron}, month = {August}, number = {3}, pages = {423--435}, posted-at = {2007-12-17 19:07:35}, priority = {3}, title = {Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.06.016}, volume = {47}, year = {2005} }

TY - JOUR ID - citeulike:406429 L3 - citeulike-article-id:406429 TI - Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. JF - Neuron VL - 47 IS - 3 SP - 423 EP - 435 AD - Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA. SN - 0896-6273 N2 - Temporal precision in spike timing is important in cortical function, interactions, and plasticity. We found that, during periods of recurrent network activity (UP states), cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials showing much higher power at all frequencies above approximately 10 Hz and more synchrony between nearby neurons. Fast-spiking inhibitory interneurons discharged strongly in relation to higher-frequency oscillations in the field potential in vivo and possess membrane, synaptic, and action potential properties that are advantageous for transmission of higher-frequency activity. Intracellular injection of synaptic conductances having the characteristics of the recorded EPSPs and IPSPs reveal that IPSPs are important in controlling the timing and probability of action potential generation in pyramidal cells. Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex. AU - Hasenstaub, A AU - Shu, Y AU - Haider, B AU - Kraushaar, U AU - Duque, A AU - McCormick, DA PY - 2005/08/04/ UR - http://dx.doi.org/10.1016/j.neuron.2005.06.016 ER -