A Biophysical Basis for the Inter-spike Interaction of Spike-timing-dependent Plasticity.

@article{citeulike:781521, abstract = {Although spike-timing-dependent plasticity (STDP) is well characterized when pre- and postsynaptic spikes are paired with a given time lag, how this generalizes for more complex spike-trains is unclear. Recent experiments demonstrate that contributions to synaptic plasticity from different spike pairs within a spike train do not add linearly. In the visual cortex conditioning with spike triplets shows that the effect of the first spike pair dominates over the second. Using a previously proposed calcium-dependent plasticity model, we show that short-term synaptic dynamics and interaction between successive back-propagating action potentials (BPAP) may jointly account for the nonlinearities observed. Paired-pulse depression and attenuation of BPAPs are incorporated into the model through the use-dependent depletion of pre- and postsynaptic resources, respectively. Simulations suggest that these processes may play critical roles in determining how STDP operates in the context of natural spike-trains.}, address = {Institute for Brain and Neural Systems, Brown University, Providence, RI, 02912, USA.}, author = {Shah, N. T. and Yeung, L. C. and Cooper, L. N. and Cai, Y. and Shouval, H. Z. }, citeulike-article-id = {781521}, doi = {http://dx.doi.org/10.1007/s00422-006-0071-y}, issn = {0340-1200}, journal = {Biol Cybern}, keywords = {bap, computational, temporal\_code}, month = {August}, number = {2}, pages = {113--121}, posted-at = {2008-06-25 20:00:16}, priority = {2}, title = {A Biophysical Basis for the Inter-spike Interaction of Spike-timing-dependent Plasticity.}, url = {http://dx.doi.org/10.1007/s00422-006-0071-y}, volume = {95}, year = {2006} }

TY - JOUR ID - citeulike:781521 L3 - citeulike-article-id:781521 TI - A Biophysical Basis for the Inter-spike Interaction of Spike-timing-dependent Plasticity. JF - Biol Cybern VL - 95 IS - 2 SP - 113 EP - 121 AD - Institute for Brain and Neural Systems, Brown University, Providence, RI, 02912, USA. SN - 0340-1200 N2 - Although spike-timing-dependent plasticity (STDP) is well characterized when pre- and postsynaptic spikes are paired with a given time lag, how this generalizes for more complex spike-trains is unclear. Recent experiments demonstrate that contributions to synaptic plasticity from different spike pairs within a spike train do not add linearly. In the visual cortex conditioning with spike triplets shows that the effect of the first spike pair dominates over the second. Using a previously proposed calcium-dependent plasticity model, we show that short-term synaptic dynamics and interaction between successive back-propagating action potentials (BPAP) may jointly account for the nonlinearities observed. Paired-pulse depression and attenuation of BPAPs are incorporated into the model through the use-dependent depletion of pre- and postsynaptic resources, respectively. Simulations suggest that these processes may play critical roles in determining how STDP operates in the context of natural spike-trains. KW - bap KW - computational KW - temporal_code AU - Shah, NT AU - Yeung, LC AU - Cooper, LN AU - Cai, Y AU - Shouval, HZ PY - 2006/08// UR - http://dx.doi.org/10.1007/s00422-006-0071-y ER -