Pathological gambling is linked to reduced activation of the mesolimbic reward system.

by: J Reuter, T Raedler, M Rose, I Hand, J Gläscher, C Büchel

Nat Neurosci, Vol. 8, No. 2. (February 2005), pp. 147-148.

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Abstract

By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.

@article{citeulike:261943, abstract = {By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.}, address = {NeuroImage Nord, Department of Neurology, Hamburg University Hospital Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.}, author = {Reuter, J. and Raedler, T. and Rose, M. and Hand, I. and Gl\"{a}scher, J. and B\"{u}chel, C. }, citeulike-article-id = {261943}, doi = {10.1038/nn1378}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {dopamine, gambling, neuroeconomics, neuroscience, reward}, month = {February}, number = {2}, pages = {147--148}, posted-at = {2005-07-25 16:06:29}, priority = {2}, title = {Pathological gambling is linked to reduced activation of the mesolimbic reward system.}, url = {http://dx.doi.org/10.1038/nn1378}, volume = {8}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:261943 L3 - citeulike-article-id:261943 TI - Pathological gambling is linked to reduced activation of the mesolimbic reward system. JF - Nat Neurosci VL - 8 IS - 2 SP - 147 EP - 148 AD - NeuroImage Nord, Department of Neurology, Hamburg University Hospital Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. SN - 1097-6256 N2 - By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity. KW - dopamine KW - gambling KW - neuroeconomics KW - neuroscience KW - reward AU - Reuter, J AU - Raedler, T AU - Rose, M AU - Hand, I AU - Gläscher, J AU - Büchel, C PY - 2005/02// UR - http://dx.doi.org/10.1038/nn1378 ER -

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