Amygdala and hippocampus volumes in pediatric major depression

@article{citeulike:1464839, abstract = {Background The purpose of this study was to measure amygdala and hippocampus volumes in pediatric major depressive disorder (MDD) and to address the question of neuroanatomical continuity with adult-onset depression.Methods We studied 20 children and adolescents with MDD (17 female subjects) and 24 healthy comparison subjects (16 female subjects) using 1.5 Tesla magnetic resonance imaging. Group differences in left and right amygdala and hippocampus volumes were examined using repeated measures analyses of covariance, adjusting for age, gender, and whole brain volume.Results Depressed children had significant reductions of left and right amygdala volumes compared with healthy subjects. Hippocampus volumes did not differ between the groups. No significant correlations were found between amygdala volumes and depressive symptom severity, age at onset, or illness duration.Conclusions Smaller amygdalas are present early in the course of pediatric depression and may predispose to the development of this disorder or perhaps more generally of childhood mood disorders. Future research should examine the longitudinal course and functional correlates of amygdala volume abnormalities in childhood-onset depression, including their possible moderation by gender.}, author = {Rosso, Isabelle M. and Cintron, Christina M. and Steingard, Ronald J. and Renshaw, Perry F. and Young, Ashley D. and Yurgelun-Todd, Deborah A. }, citeulike-article-id = {1464839}, journal = {Biological Psychiatry}, keywords = {adolescents, amygdala, depression, hippocampus}, month = {January}, number = {1}, pages = {21--26}, posted-at = {2007-07-18 13:19:36}, priority = {2}, title = {Amygdala and hippocampus volumes in pediatric major depression}, url = {http://www.sciencedirect.com/science/article/B6T4S-4F1HPHV-8/2/faefa2521817953f987a616b63299dcf}, volume = {57}, year = {2005} }

TY - JOUR ID - citeulike:1464839 L3 - citeulike-article-id:1464839 TI - Amygdala and hippocampus volumes in pediatric major depression JF - Biological Psychiatry VL - 57 IS - 1 SP - 21 EP - 26 N2 - Background The purpose of this study was to measure amygdala and hippocampus volumes in pediatric major depressive disorder (MDD) and to address the question of neuroanatomical continuity with adult-onset depression.Methods We studied 20 children and adolescents with MDD (17 female subjects) and 24 healthy comparison subjects (16 female subjects) using 1.5 Tesla magnetic resonance imaging. Group differences in left and right amygdala and hippocampus volumes were examined using repeated measures analyses of covariance, adjusting for age, gender, and whole brain volume.Results Depressed children had significant reductions of left and right amygdala volumes compared with healthy subjects. Hippocampus volumes did not differ between the groups. No significant correlations were found between amygdala volumes and depressive symptom severity, age at onset, or illness duration.Conclusions Smaller amygdalas are present early in the course of pediatric depression and may predispose to the development of this disorder or perhaps more generally of childhood mood disorders. Future research should examine the longitudinal course and functional correlates of amygdala volume abnormalities in childhood-onset depression, including their possible moderation by gender. KW - adolescents KW - amygdala KW - depression KW - hippocampus AU - Rosso, Isabelle AU - Cintron, Christina AU - Steingard, Ronald AU - Renshaw, Perry AU - Young, Ashley AU - Yurgelun-Todd, Deborah PY - 2005/01/01/ UR - http://www.sciencedirect.com/science/article/B6T4S-4F1HPHV-8/2/faefa2521817953f987a616b63299dcf ER -